Click Reactions in Organic Synthesis
John Wiley & Sons, Jun 22, 2016 - Science - 360 pages
This book on click reactions to focus on organic synthesis, this reference work describes the click concept and underlying mechanisms as well as the main applications in various fields. As such, the chapters cover green chemical synthesis, metal-free click reactions, synthesis of pharmaceuticals, peptides, carbohydrates, DNA, macrocycles, dendrimers, polymers, and supramolecular architectures.
By filling a gap in the market, this is the ultimate reference for synthetic chemists in academia and industry aiming for a fast and simple design and synthesis of novel compounds with useful properties.
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13 Base catalyzed thiolepoxy ringopening
Applications of Click Chemistry in Drug
Green Chemical Synthesis and Click
Synthesis of Substituted 123Triazoles
Applications of the CuCatalyzed Azide
Synthesis of Diverse CarbohydrateBased
AzideAlkyne Click Reaction in Polymer
ThiolBased Click Chemistry
and Nucleic Acids using Huisgens 3+2 AzideAlkyne
Catalytic Enolate Intermediates
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1,3-dipolar cycloaddition 1,4-disubstituted acid activity agents alkyl amide bond amine analogs Angew anions anticancer applications approach aryl aryl azides ATRP azide and alkyne azide–alkyne cycloaddition azido benzyl Bioconjugate biological Bioorg catalyst catalyzed cell chain end Chem Chen click chemistry click reaction clickable complex compounds conjugated copolymer copper(I coworkers cross-linked Cu(I CuAAC reaction cyclic polymers cycloaddition reaction cyclooctyne dendrimers dendron derivatives developed disubstituted 1,2,3-triazoles efficient ester excellent yields Figure fluorescent Fokin formation functional groups glycoconjugates glycosyl Green Chem high yields Huisgen hydrogen IC50 values inhibitors intermediate ketones ligands linear polymers macrocycle Macromolecules modified moiety molecular molecules monomer nanoparticles nucleophilic nucleoside one-pot Organocatalytic peptides polymerization polymers potential prepared presence propargyl protein react reactive regioselective reported room temperature Scheme Sharpless sodium sodium azide solvent SPAAC strategy structures substituted substrates terminal alkynes Tetrahedron Lett thiol thiol-based click thiol–ene triazole triazole ring triazole-linked triazolylglycoconjugates utilized Wang Zhang