Gastrointestinal Endocrinology: Receptors and Post-Receptor MechanismsJames Thompson Gastrointestinal Endocrinology: Receptors and Post-Receptor Mechanisms provides information pertinent to the fundamental aspects of receptors and post-receptor mechanisms. This book discusses a variety of topics, including normal and neoplastic growth, molecular biology and genetics, and actions of gut hormones and their clinical importance. Organized into 37 chapters, this book begins with an overview of the initial step in the interaction of a gastrointestinal peptide with its target cell. This text then examines the concept that the receptor proteins are a major control mechanism by which a cell engineers the effects of a hormone. Other chapters consider the epidermal growth factor (EGF), which is a heat-stable polypeptide that exerts both short- and long-term regulatory effects on various cellular processes. This book discusses as well the developments in the ability to measure the concentration of ionized calcium in cells. The final chapter deals with the hormonal mechanisms in gallbladder motility. This book is a valuable resource for biochemists. |
Contents
| 1 | |
| 13 | |
Chapter 3 Multifunctional Role of the Epidermal Growth Factor Receptor in the Regulation of Cell Growth | 33 |
Chapter 4 Regulation of Intracellular Calcium Release and Calcium Uptake by Inositol 145trisphosphate in Exocrine Glands | 43 |
Chapter 5 Cellular Calcium and Phospholipid Metabolism Mediate Pancreatic Enzyme Secretion | 59 |
Chapter 6 Heterogeneity of Receptors and Signal Transduction Pathways in Smooth Muscle Cells of the Gut | 73 |
Chapter 7 Biochemical Characterization of Receptors for the Cholecystokinin Family of Hormones | 81 |
Ability to Distinguish Various Classes of Cholecystokinin Receptors | 95 |
Chapter 21 Effect of Gastrointestinal Hormones on Neoplastic Growth | 273 |
Chapter 22 Gastrin is a Hormonal Stimulant of the Intestinal Gastric and Cephalic Phases of Acid Secretion in Dogs | 285 |
Chapter 23 Pancreatic Enzymes in Feedback Regulation of Cholecystokinin Release | 297 |
Chapter 24 Bile Salts in Cholecystokinin Feedback | 307 |
Chapter 25 Neuronal Actions of Cholecystokinin | 321 |
Chapter 26 The Role of Pancreatic Polypeptide in Glucose Metabolism | 333 |
Chapter 27 Immunologie and Biologic Properties of GlucagonLike Peptide1 GLP1 | 359 |
Chapter 28 Peptide YY Release and Actions | 371 |
Chapter 9 Cholecystokinin Gene Expression | 115 |
Chapter 10 Human and Mouse Amylase Genes in Transgenic Mice | 125 |
Chapter 11 Studies on Gastrin Posttranslational Processing | 137 |
Chapter 12 CellSpecific Expression and Processing of Procholecystokinin and Progastrin | 147 |
Chapter 13 Pancreatic Polypeptide Peptide YY and Secretin Gene Expression | 155 |
Chapter 14 Modern Imaging at the Cellular Level | 169 |
Chapter 15 Gastrointestinal Peptides and Autocrine Growth Effects | 187 |
Chapter 16 Primary Cultures of Pancreatic Acinar Cells | 199 |
Chapter 17 Trophic Effects of Cholecystokinin on the Exocrine Pancreas | 211 |
Chapter 18 Involvement of Somatostatin in Pancreatic Growth | 225 |
Chapter 19 Pancreatic Adaptation Involves Regulation of Gene Expression by Cholecystokinin | 241 |
Differential Responses to Peptides | 257 |
Chapter 29 Receptor Mediated Biologic Actions of Cholecystokinin | 387 |
Chapter 30 The Cell Biology of Acute Pancreatitis | 397 |
Treatment of Gut Endocrinopathies and a Mechanism of Action | 407 |
Chapter 32 Cytoprotective Effects of Somatostatin on Experimental Diabetes | 423 |
Chapter 33 Actions of Parathyroid Hormone on the Gut | 433 |
Chapter 34 Inhibitory Mechanisms of the Exocrine Pancreas | 445 |
Chapter 35 AutocrineParacrine Growth Factors of Human Malignancies | 455 |
Chapter 36 Clinical Syndromes of Gut Hormones | 479 |
Chapter 37 Hormonal Mechanisms in Gallbladder Motility | 491 |
| 505 | |
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Common terms and phrases
acid secretion acinar cells acini action activity affinity amino acid amylase amylase release analogue antibody autocrine binding Biochem Biol Chem biologic bombesin caerulein calcium calcium uptake CCK receptor antagonist CCK-RP cDNA cell lines cellular characterization chronic pancreatitis colon concentrations culture diabetes digestive enzymes dogs dose effect endogenous enzyme Figure gallbladder gastrin gastrin receptor Gastroenterology gene glucagon glucose guinea pig hepatic glucose hormone human increase infusion inhibition inhibitory insulin intestinal intracellular isolated mechanism mediated membranes mice molecular mRNA mucosa muscle cells neurons neurotensin normal pancreatic acinar cells pancreatic enzyme secretion pancreatic growth pancreatic polypeptide peptide YY perfusion Physiol physiologic plasma CCK probe proglumide protein kinase rat pancreatic receptor antagonist regulation release of CCK response Sandostatin SBTI SCLC cell secretin sequence smooth muscle somatostatin specific SRIF stimulation studies synthesis Thompson JC tissue trypsin tumor VIPoma vitro vivo zymogen