Bioinformatics: Sequence and Genome Analysis
As more species' genomes are sequenced, computational analysis of these data has become increasingly important. The second, entirely updated edition of this widely praised textbook provides a comprehensive and critical examination of the computational methods needed for analyzing DNA, RNA, and protein data, as well as genomes. The book has been rewritten to make it more accessible to a wider audience, including advanced undergraduate and graduate students. New features include chapter guides and explanatory information panels and glossary terms. New chapters in this second edition cover statistical analysis of sequence alignments, computer programming for bioinformatics, and data management and mining. Practically oriented problems at the ends of chapters enhance the value of the book as a teaching resource. The book also serves as an essential reference for professionals in molecular biology, pharmaceutical, and genome laboratories.
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Boltzmann distribution 344345
Boltzmann gas constant
Bond angles protein structure 420422438481
Bonferroni correction 615653
CaBIO 572 575
Multiple Sequence Alignment
HOW MULTIPLE SEQUENCE ALIGNMENT
Sequence Database Searching for Similar
Cancer Bioinformatics Infrastructure Obiects caBIO1 572575
Cancer genome hybridization CGH1 619620
CASP critical assessment of structure prediction1 471484
Other editions - View all
algorithm alignment score amino acid amino acid substitution base pairs Bioinformatics Biol biological BioPerl BLAST blocks BLOSUM calculated cDNA changes chromosomes CLUSTALW clusters codon column database search database sequence described in Chapter distance DNA sequences domains dynamic programming eukaryotic evolutionary example exons FASTA fold frequency function gap penalties GenBank gene expression gene prediction genetic genome sequence global alignment identify introns large number length log odds scores matches ment method microarray modules motif mRNA multiple sequence alignment mutation Nucleic Acids organism output Perl phylogenetic analysis probability produce protein sequences protein structure proteome PSSM query sequence regions related sequences represent residues sample scoring matrix script secondary structure sequence analysis sequence database sequence positions sequence similarity server similarity searches statistical structure prediction substitution matrices Table tein three-dimensional structure tion tree variable window
Page 547 - ... recommendations of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology...
Page 545 - II, Sequence determination of the entire genome and assignment of potential protein-coding regions. DNA Res.
Page 114 - Markowitz E. ( 1970). An improved method for determining codon variability in a gene and its application to the rate of fixation of mutations in evolution. Biochem. Genet., 4, 579-593.
Page 25 - Base-calling of automated sequencer traces using phred. I. Accuracy assessment. Genome Res.