Bioinformatics: Sequence and Genome Analysis
As more species' genomes are sequenced, computational analysis of these data has become increasingly important. The second, entirely updated edition of this widely praised textbook provides a comprehensive and critical examination of the computational methods needed for analyzing DNA, RNA, and protein data, as well as genomes. The book has been rewritten to make it more accessible to a wider audience, including advanced undergraduate and graduate students. New features include chapter guides and explanatory information panels and glossary terms. New chapters in this second edition cover statistical analysis of sequence alignments, computer programming for bioinformatics, and data management and mining. Practically oriented problems at the ends of chapters enhance the value of the book as a teaching resource. The book also serves as an essential reference for professionals in molecular biology, pharmaceutical, and genome laboratories.
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Gene Prediction and Regulation
Protein Classification and Structure Prediction
Bond angles protein structure420422438481
Multiple Sequence Alignment
HOW MULTIPLE SEQUENCE ALIGNMENT
Sequence Database Searching for Similar
Prediction of RNA Secondary Structure
Boltzmann distribution 344345
Boltzmann gas constant344
Bioinformatics Programming Using Perl and Perl
Cancer Bioinformatics Infrastructure Objects cabi0572575
Analysis of Microarrays
Cancer genome hybridization CGH619620
CASP critical assessment of structure prediction471484
CCAAT box transcription 394395
Other editions - View all
algorithm alignment score amino acid amino acid substitution base pairs Bioinformatics Biol biological BLAST blocks calculated changes chromosomes clusters codon column database search database sequence described in Chapter distance DNA sequences domains dynamic programming eukaryotic evolutionary example FASTA fold format frequency function gap penalties GenBank gene expression gene prediction genetic genome sequence hidden Markov model identify introns large number length log odds scores matches ment method microarray modules motif mRNA multiple sequence alignment mutation Nucleic Acids Nucleic Acids Res organisms output Perl probability produce protein families protein sequences protein structure proteome PSSM query sequence regions related sequences represent residues samples scoring matrix script secondary structure sequence analysis sequence database sequence positions sequence similarity server similarity searches statistical structure prediction substitution matrices Table tein three-dimensional structure tion tree variable window
Page 517 - ... recommendations of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology...
Page 515 - II, Sequence determination of the entire genome and assignment of potential protein-coding regions. DNA Res.
Page 114 - Markowitz E. ( 1970). An improved method for determining codon variability in a gene and its application to the rate of fixation of mutations in evolution. Biochem. Genet., 4, 579-593.
Page 25 - Base-calling of automated sequencer traces using phred. I. Accuracy assessment. Genome Res.