Bioinformatics: Sequence and Genome Analysis

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CSHL Press, 2004 - Science - 692 pages
15 Reviews
As more species' genomes are sequenced, computational analysis of these data has become increasingly important. The second, entirely updated edition of this widely praised textbook provides a comprehensive and critical examination of the computational methods needed for analyzing DNA, RNA, and protein data, as well as genomes. The book has been rewritten to make it more accessible to a wider audience, including advanced undergraduate and graduate students. New features include chapter guides and explanatory information panels and glossary terms. New chapters in this second edition cover statistical analysis of sequence alignments, computer programming for bioinformatics, and data management and mining. Practically oriented problems at the ends of chapters enhance the value of the book as a teaching resource. The book also serves as an essential reference for professionals in molecular biology, pharmaceutical, and genome laboratories.
 

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Awesome book. I have been referring this book for past couple of years and it always proved to be the best!

Contents

2
30
CHAPTER 2
39
CHAPTER 3
48
Alignment of Pairs of Sequences
65
CHAPTER 4
95
Introduction to Probability and Statistical
121
Block alignment with Bayes block aligner 152157
152
CHAPTER 5
155
CHAPTER 7
248
Phylogenetic Prediction
281
Boltzmann distribution 344345
334
Boltzmann gas constant
344
Bond angles protein structure 420422438481
420
Bonferroni correction 615653
467
CaBIO 572 575
509
Modules
549

Multiple Sequence Alignment
164
HOW MULTIPLE SEQUENCE ALIGNMENT
170
Block analysis
194
CHAPTER 6
207
Sequence Database Searching for Similar
227
Cancer Bioinformatics Infrastructure Obiects caBIO1 572575
572
Cancer genome hybridization CGH1 619620
619
Index
667
CASP critical assessment of structure prediction1 471484
671
Copyright

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Common terms and phrases

Popular passages

Page 547 - ... recommendations of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology...
Page 545 - II, Sequence determination of the entire genome and assignment of potential protein-coding regions. DNA Res.
Page 114 - Markowitz E. ( 1970). An improved method for determining codon variability in a gene and its application to the rate of fixation of mutations in evolution. Biochem. Genet., 4, 579-593.
Page 25 - Base-calling of automated sequencer traces using phred. I. Accuracy assessment. Genome Res.
Page 59 - Ewing, B. and Green, P. (1998) Base-calling of automated sequencer traces using phred. II. Error probabilities.

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