Papillomavirus Research: From Natural History to Vaccines and Beyond

Front Cover
M. Saveria Campo
Horizon Scientific Press, 2006 - Science - 423 pages
2 Reviews
Papillomaviruses are oncogenic DNA tumor viruses that infect humans and animals. Human papillomavirus is one of the most common causes of sexually transmitted infection in the world and can also cause cancer. Papillomavirus research has been revolutionized in recent years with the advent of new technologies such as organotypic raft cultures, virus-like particles, and transgenic mice. New facets of virion structure, life cycle, immunology, and oncogenicity have recently emerged. In this timely book, leading scientists review current aspect of papillomavirus research providing a fascinating insight into papillomavirus molecular biology, interactions with the host, immunology, and vaccine development. Topics covered include epidemiology and taxonomy, phylogenetic analysis, gene expression, regulation of DNA replication, transcription factor proteins, organotypic raft cultures, virus-like particles, and much more. Essential reading for scientists and researchers working on papillomavirus and a recommended text for anyone involved with antiviral drug and vaccine development.
 

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Contents

Linking Human Papillomaviruses to Cervical Cancer A Long and Winding Road
3
Phylogeny and Taxonomy of Papillomaviruses
11
Epidemiology of Human Papillomavirus Infections and Associations with Cervical Cancer New Opportunities For Prevention
19
Gene Expression of Papillomaviruses
41
Mechanisms and Regulation of Papillomavirus DNA Replication
53
The Papillomavirus TranscriptionReplication Factor E2 Structure Function Cancer and Therapy
73
The E4 Protein A Late Starter
83
Biological Activities of Papillomavirus E5 Proteins
97
HPV and Oesophageal Carcinoma
229
Recurrent Respiratory Papillomatosis HPV and Impact on Host Response
255
The Cutaneous Human Papillomavirus Types and Nonmelanoma Skin Cancer
269
Papillomaviruslike Particles and Their Applications in Molecular Virology Human Serology and Vaccines
279
Immunobiology of Papillomaviruses
311
Immune Evasion in Genital Papillomavirus Infection and Cervical Cancer Role of Cytokines and Chemokines
321
HPV Vaccines
341
HPV Vaccines in Plants An Appetising Solution to Control Infection and Associated Cancers
357

The Role of the HPV E6 Oncoprotein in Malignant Progression
115
The Biology of the E7 protein of HPV16
133
Organotypic Raft Cultures and the Study of the Natural History of Papillomavirus
145
Early Events in the Papillomaviral Lifecycle
175
Late Events in the Life Cycle of Human Papillomaviruses
193
Transgenic Mouse Models for the In Vivo Analysis of Papillomavirus Oncogene Function
213
Bovine Papillomavirus Old system New Lessons?
373
Bovine Papillomaviruses and Equine Sarcoids
389
Rabbit Viral Papillomas and Carcinomas Model Diseases for Human Papillomavirus Infections and Associated Carcinogenesis
399
Index
421
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