Alzheimer's Disease: Clinical and Treatment Perspectives
Neal R. Cutler, C. G. Gottfries, K. Siegfried
Wiley, Jul 11, 1995 - Psychology - 198 pages
Progress in the basic and clinical research of Alzheimer?s disease has been substantial in recent years and has contributed significantly to our understanding of the pathology which underlies the disease process. Although there has been no treatment breakthrough, advances in neuroscience research have provided a clearer focus for the clinical development of promising therapeutic strategies. Presented here is a comprehensive and authoritative account of the latest discoveries on Alzheimer?s disease. Crucial areas of basic research are discussed as well as viable neurotransmitter treatment approaches and a method for determining the proper dose to use in clinical drug trials. Written by an international group of authors, the book will be of value to all researchers in Alzheimer?s disease and to neuroscientists, neurologists and psychiatrists.
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The Diagnosis of Alzheimers Disease
Biochemical Aspects and CSF Markers in Alzheimers
Brain Imaging and Alzheimers Disease 27
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acetylcholine activity AD/SDAT adrenergic adverse events agonists Alzheimer type Alzheimer's disease aminoacridines amyloid precursor protein assessment besipirdine biochemical markers Blennow Bowen Brain Res bridging study cells cerebral cortex cerebrospinal fluid cholinergic cholinesterase clinical diagnosis clonidine cognitive compounds concentrations correlated cortical criteria Cutler Davis deficits degeneration disorders dosages dose double-blind drug effects efficacy elderly enzyme evidence Francis frontal gangliosides Gottfries heimer's disease hippocampal hippocampal atrophy immunoreactivity increased inhibition inhibitor lesions lipids loss McGeer membrane memory metabolism mg/day microglia muscarinic Natl Acad Neurobiol Aging Neurochem neurofibrillary tangles Neurology Neurosci neurotransmitter normal p-amyloid pathology patients with Alzheimer's peptide Perry phase physostigmine Pick's disease placebo postmortem potential Proc Psychiatry pyramidal neurons receptors Scheltens Selkoe senile dementia senile plaques Siegfried significant symptoms synaptic tacrine tau proteins temporal lobe therapeutic tion tolerance toxicity transmitter velnacrine ventricular Wallin white matter