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abnormalities affective psychosis amisulpride analysis antipsychotic appraisal aripiprazole assessment associated at-risk mental baseline basic symptoms behaviour brain British Journal cingulate clinical cognitive cognitive therapy control group correlation criteria deficits Department of Psychiatry depression developed psychosis diagnosis differences dopamine dopaminergic duration of untreated early detection effects emotional dysfunction experiences first-episode psychosis follow-up function Garety grey matter grey matter volume gyrus hallucinations high risk imaging journal of Psychiatry King's College London Klosterkotter lnstitute of Psychiatry Maastricht University magnetic resonance imaging McGorry mean s.d. measures MRCPsych negative symptoms neurocognitive neuropsychological olanzapine PANSS participants phrenia positive symptoms potential prodrome predictive Psychological Medicine psychotic disorder psychotic symptoms rates risk of psychosis sample Sao Paulo Scale schizo Schizophrenia Research schizotypy scores significant social social defeat striatal sub-scales suicide temporal Test tion treatment trial ultra-high risk University of Cologne virtual reality voxel voxel-based morphometry white matter Yung