Hypoglycemia: Pathophysiology, Diagnosis, and Treatment
Hypoglycemia--low blood sugar--is a common problem in diabetic patient s taking insulin. This is a comprenhensive treatment of hypoglycemia w ritten by one of the most prominent investigators in the field who is also an active clinician. It applies up-to-date concepts of the physio logy of glucose counter-regulation--the mechanisms that normally preve nt or rapidly correct hypoglycemia and thus defend the brain from its devastating effects--and of the pathophysiology of those mechanisms wh ich were largely unknown when previous books on the topic were publish ed, to the diagnosis and treatment of the clinical problem. While its early chapters provide a detailed scientific background, its clinical chapters (on hypoglycemia in diabetes mellitus, the hypoglycemic disor ders and the approach to the patient with hypoglycemia) provide much p ractical guidance for physicians.
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alanine autonomic B-adrenergic Boyle Brunetti C-peptide catecholamines cause cemia Chapter Clin Endocrinol Metab Clin Invest clinical correction of hypoglycemia cortisol counterregulatory hormone Cryer decreased DeFeo deficiency diabetes mellitus disorder drugs effect endogenous glucose production endogenous hyperinsulinism epinephrine epinephrine response episodes Fanelli fasting hypoglycemia fatty acid glucagon glucagon and epinephrine glucagon response glucagon secretion gluconeogenesis gluconeogenic glucose metabolism glucose transport glucose uptake glucose utilization glycemia glycemic thresholds glycogen glycogenolysis growth hormone Haymond healthy humans hepatic hepatic glucose production hyperinsulinemia hyperinsulinism hypo hypogly hypoglyce hypoglycemia unawareness iatrogenic iatrogenic hypoglycemia IDDM insulin levels insulin secretion insulin-induced insulinoma intensive therapy intravenous J.E. Gerich lipolysis liver lower plasma glucose mechanisms mg/dL Mitrakou mmol/L neural norepinephrine normal overnight fast pancreatic physiological plasma glucose concentration plasma glucose levels postabsorptive postprandial prevention of hypoglycemia proinsulin rates of glucose renal responses to hypoglycemia Rizza role S.D. Shah severe hypoglycemia somatostatin substrate sulfonylurea suppressed symptoms tion tumors W.E. Clutter