Peptide Drug Discovery and Development: Translational Research in Academia and Industry
Miguel Castanho, Nuno Santos
John Wiley & Sons, Oct 24, 2011 - Medical - 450 pages
Filling a real knowledge gap, this handbook and ready reference is both modern and forward-looking in its emphasis on the "bench to bedside" translational approach to drug development.
Clearly structured into three major parts, the book stakes out the boundaries of peptide drug development in the preclinical as well as clinical stages. The first part provides a general background and focuses on the characteristic strengths and weaknesses of peptide drugs.
The second section contains five cases studies of peptides from diverse therapeutic fields, and the lessons to be learned from them, while the final part looks at new targets and opportunities, discussing several drug targets and diseases for which peptide drugs are currently being developed.
What people are saying - Write a review
We haven't found any reviews in the usual places.
Marketing Antimicrobial Peptides A Critical Academic
Oral Peptide Drug Delivery Strategies to Overcome
Rational Design of Amphipathic αHelical and Cyclic
ConotoxinBased Leads in Drug Design
Plant Antimicrobial Peptides From Basic Structures
Peptide Drugs Translational Tales
HIV vs HIV Turning HIVDerived Peptides into Drugs
Sifuvirtide A Novel HIV1 Fusion Inhibitor
Whither Peptide Drugs? Peptides Shaping
Translation of Motilin and Ghrelin Receptor Agonists
Of Mice and Men Translational Research on Amylin
Peptides and Polypeptides as Immunomodulators
Development of Antibody Fragments for Therapeutic
Omiganan Pentahydrochloride A Novel Broad
absorption agents amino acid amphipathic AMPs amylin analgesic antibodies antigen antimicrobial activity antimicrobial peptides Arnon autoimmune bacterial binding Biol body weight brain C-terminal cells Chem compound conformation conotoxins Curr cytokines defensin delivery diabetes disease domain dose effects efficacy enfuvirtide enhance enzymes erythromycin expression Figure food intake fusion inhibitor gastric emptying gastrointestinal gastroparesis ghrelin ghrelin receptor glatiramer acetate HCMV helical hemolytic activity HIV-1 fusion hormone human hydrophobic immune immunodeficiency virus immunomodulation improved increase induced infections inhibition insulin interaction intestinal leptin ligand lipid membrane metabolic mice molecular molecules motilin motility Natl neurons neuropeptide non-polar face novel NS3 protease obesity omiganan opioid oral pathogens patients peptide drugs Pharm Pharmacol plant platelet polypeptide potential pramlintide prokinetic protein rats recombinant residues resistance response role romiplostim sequence Sifuvirtide specific strategies structure studies synthetic T-cells target therapeutic therapy thrombopoietin treatment viral vitro vivo weight loss