Placebo Effects: Understanding the Mechanisms in Health and Disease
The placebo effect is one of the most widely used and familiar terms within science and medicine, yet it is not always clear just what we mean by a placebo effect.Though we might describe a placebo effect as being 'all in the mind', we now know that there is a genuine neurobiological basis to this phenomenon. In recent years our knowledge of the neural bases of the placebo effect has developed markedly, and we now have a far better understanding of how it can influence both the course of a disease and the response to therapy. This is the first book to critically review the mechanisms of placebo and placebo-related effects across all medical conditions, diseases, and therapeutic interventions. It describes the main psychological and biological mechanisms of placebo responsiveness across the entire spectrum of medical disciplines. In addition, it looks at the clinical and ethical implications of administering placebos. Exhaustive in its coverage, and written by a world authority in the field, this is the definitive reference text to the placebo effect - one that will be essential for researchers and clinicians across a wide range of medical specialities.
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activity acupuncture Amanzio analgesic analgesic response anxiety assessed associated Behavior Benedetti F Brain Research buprenorphine cingulate cortex classical conditioning clinical improvement clinical trials cognitive Colloca conditioned response conditioned stimulus context Copyright cortisol decrease deep-brain stimulation disorders dopamine double-blind drug endogenous opioid example expectation experimental factors functions hidden hormone Hrobjartsson hyperalgesia immune increase induced injection insulin investigators involved irritable bowel syndrome Journal of Medicine Journal of Neuroscience ketorolac mechanisms meta-analysis migraine morphine motor naloxone neural neurons nicotine nocebo effect nucleus accumbens orbitofrontal cortex outcome pain painkiller Parkinson's disease patients performed pharmacological placebo administration placebo analgesia placebo and placebo-related placebo effect placebo groups placebo response placebo treatment placebo-controlled placebo-related effects prefrontal cortex Price DD proglumide psychological psychotherapy randomized real placebo received receptors reduced regions role saline sham showed spontaneous remission striatum subjects subthalamic nucleus Sumatriptan surgery symptoms therapeutic therapy tion unconditioned ventral verbal suggestions