Transport in the Liver: Proceedings of the 74th Falk Symposium Held in Heidelberg, Germany, January 27-28, 1994
Dietrich Keppler, Kurt Jungermann
Kluwer Academic Publishers, Jan 1, 1994 - Health & Fitness - 258 pages
Important functions of the liver are controlled by transport across different membrane domains. Advances in molecular cell biology have contributed to a better understanding of transport mechanisms in hepatocytes. The chapters in this book, the proceedings of the 74th Falk Symposium held in Heidelberg, Germany, 27-28 January 1994, discuss the current concepts in transport of low molecular weight substances across the sinusoidal membrane, intracellular events in conjugation and transport, as well as export across the canalicular hepatocyte membrane. Recent developments in primary-active ATP-dependent transport include the analysis of multidrug resistance gene products expressed in the canalicular membrane.
Transport processes will be discussed on the level of the carrier molecules, on the cellular level, as well as in the intact organ. In addition, the regulation of transport systems, their inhibition and induction, as well as genetic defects of transport systems will be addressed. This book will contribute to the exchange of information between basic scientists and clinical hepatologists in the rapidly expanding area of membrane transport.
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Mechanisms in membrane transport
Physiological utility of biliary secretion and excretion
Regulation of transport across hepatocyte membranes
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Acad Sci USA acid uptake activity amino acids antibody ATP-dependent transport basolateral bile acid bile acid transport bile flow bile salt biliary excretion bilirubin Biochem Biol Chem Boyer JL canalicular membrane vesicles canalicular transport cDNA cell swelling cell volume cholate cholestasis Clin Invest cloning colchicine concentration conjugated cytosolic digoxin efflux excretion into bile expression Falk Symposium fatty acid function glucose transport glucose transport protein glucose-6-phosphatase glutathione GSH transporter GSSG hepatic hepatocytes Hepatology human increased inhibition intestine intracellular isolated hepatocytes kinetic lipid liver canalicular membrane liver plasma membrane MDR1 mdr2 mechanism mediated Meier PJ microsomal molecular molecules mRNA multidrug resistance Na"-dependent Natl Acad Sci norcholansulphonate oocytes organic anion transport P-glycoprotein perfused rat liver phospholipid Physiol plasma membrane plasma membrane vesicles Proc Natl Acad rat hepatocytes rat liver canalicular regulation secretion sinusoidal stimulation substrate symporter System ASC taurocholate excretion tissues transfection transport system umol/l vesicles