Transport in the Liver: Proceedings of the 74th Falk Symposium Held in Heidelberg, Germany, January 27-28, 1994

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Dietrich Keppler, Kurt Jungermann
Kluwer Academic Publishers, Jan 1, 1994 - Health & Fitness - 258 pages
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Important functions of the liver are controlled by transport across different membrane domains. Advances in molecular cell biology have contributed to a better understanding of transport mechanisms in hepatocytes. The chapters in this book, the proceedings of the 74th Falk Symposium held in Heidelberg, Germany, 27-28 January 1994, discuss the current concepts in transport of low molecular weight substances across the sinusoidal membrane, intracellular events in conjugation and transport, as well as export across the canalicular hepatocyte membrane. Recent developments in primary-active ATP-dependent transport include the analysis of multidrug resistance gene products expressed in the canalicular membrane.
Transport processes will be discussed on the level of the carrier molecules, on the cellular level, as well as in the intact organ. In addition, the regulation of transport systems, their inhibition and induction, as well as genetic defects of transport systems will be addressed. This book will contribute to the exchange of information between basic scientists and clinical hepatologists in the rapidly expanding area of membrane transport.

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Contents

Mechanisms in membrane transport
3
Physiological utility of biliary secretion and excretion
17
Regulation of transport across hepatocyte membranes
32
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