Transport in the LiverD. Keppler, K. Jungermann Important functions of the liver are controlled by transport across different membrane domains. Advances in molecular cell biology have contributed to a better understanding of transport mechanisms in hepatocytes. The chapters in this book, the proceedings of the 74th Falk Symposium held in Heidelberg, Germany, 27--28 January 1994, discuss the current concepts in transport of low molecular weight substances across the sinusoidal membrane, intracellular events in conjugation and transport, as well as export across the canalicular hepatocyte membrane. Transport processes are discussed on the level of the carrier molecules, on the cellular level, as well as in the intact organ. In addition, the regulation of transport systems is addressed. An invaluable contribution to the exchange of information between basic scientists and clinical hepatologists in the rapidly expanding area of membrane transport. |
Contents
Mechanisms in membrane transport | 3 |
Physiological utility of biliary secretion and excretion | 17 |
Regulation of transport across hepatocyte membranes | 32 |
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Acad Sci USA acid uptake activity amino acids antibody ATP-dependent transport basolateral bile acid bile acid transport bile flow bile salt biliary secretion bilirubin Biochem Biol Chem Boyer JL canalicular membrane vesicles canalicular transport cDNA cell swelling cell volume cholate cholestasis Clin Invest cloning concentration conjugated cytosolic digoxin efflux excretion into bile expression Falk Symposium fatty acid function Gerok glucose transport glucose transport protein glucose-6-phosphatase glutamine glutathione GSSG hepatic hepatocytes Hepatology human increased inhibition intracellular isolated hepatocytes kinetic lipid liver canalicular membrane liver plasma membrane mdr gene mdr1 mdr1b mdr2 mechanism mediated Meier PJ microsomal mmol/l molecular molecules mRNA multidrug resistance Natl Acad Sci norcholansulphonate oocytes organic anion transport P-glycoprotein perfused rat liver phospholipid Physiol plasma membrane plasma membrane vesicles Proc Natl Acad quinidine rat hepatocytes rat liver canalicular regulation sinusoidal stimulation substrate symporter System ASC taurocholate excretion tissues transfection transport system vesicles