Regenerative Medicine I: Theories, Models and Methods

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Ioannis V. Yannas
Springer Science & Business Media, Feb 10, 2005 - Medical - 193 pages
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Organ regeneration, once unknown in adult mammals, is at the threshold of maturity as a clinical method for restoration of organ function in humans. Several laboratories around the world are engaged in the development of new tools such as stem cells and biologically active scaffolds. Others are taking fresh looks at well-known clinical problems of replacement of a large variety of organs: Bone, skin, the spinal cord, peripheral nerves, articular cartilage, the conjunctiva, heart valves and urologic organs. Still other investigators are working out the mechanistic pathways of regeneration and the theoretical implications of growing back organs in an adult. The time has come to present a collection of these efforts from leading practitioners in the field of organ regeneration.

 

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Contents

Yannas
2
Facts and Theories of Induced Organ Regeneration
3
The Defect Closure Rule
16
Structural Determinants of Scaffold Regenerative Activity
22
Simultaneous In Vivo Regeneration of Neodermis Epidermis
31
Theoretical Implications of the Data
34
Regenerative Capacity and the Developing Immune System
39
Vertebrate Limb Regeneration
65
Mammalian Fetal Organ Regeneration
83
Liver Regeneration
101
Stem Cells in CNS and Cardiac Regeneration
135
A Model for Studying Skin Regeneration in Isolation
161
Subject Index
191
Spinal Cord Regeneration
193
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