Handbook of Multiple SclerosisStuart D. Cook This work integrates the environmental triggers of multiple sclerosis (MS) with genetic susceptibility to the disease, and presents developments in MS investigation. It highlights epidemiology, aetiology, pathogenesis, pathology, clinical features, and therapy. The book explains the most efficacious treatment strategies, including beta interferons, copolymer 1, cladribine, imuran, methotrexate, corticosteroids, and IV gamma globulin as well as symptomatic therapies such as symmetrel, cylert, tegretol, dilantin, lioresol, antidepressants and ditropan. |
Contents
Genetics of Multiple Sclerosis | 19 |
Experimental Models of VirusInduced Demyelination | 53 |
Evidence for a Viral Etiology of Multiple Sclerosis | 97 |
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4-aminopyridine abnormal ACTH activity acute Ann Neurol antibodies antigen Arch Neurol associated astrocytes autoimmune encephalomyelitis axons CD4+ cells central nervous system cerebrospinal fluid chronic progressive Clin clinical conduction copolymer correlation corticosteroid cytokines demyelinated axons disability dose double-blind EDSS encephalitogenic epitopes evoked potentials experimental allergic encephalomyelitis experimental autoimmune encephalomyelitis factor function genes genetic human immune response immunoglobulin Immunol immunosuppression increased induced infection inflammatory inhibition interferon intravenous lesions lymphocytes macrophages methylprednisolone mice molecules monoclonal multiple sclerosis multiple sclerosis patients murine myelin basic protein Na+ channels nerve Neuroimmunol Neurol Neurosurg Psychiatry Neurol Sci Neurology normal oligoclonal oligodendrocytes optic neuritis oral pathogenesis patients with multiple peptide plaques plasma progressive multiple sclerosis relapse relapsing-remitting role serum significant specific spinal cord studies symptoms T-cell receptor Theiler's therapeutic therapy tion tissue treatment trial viral virus visual vitro white matter