Endocrine Facets of AgeingSocial and medical developments have recently led to a dramatic increase in life expectancy. This has inspired the study of organismic changes associated with healthy ageing, in particular the erosion of homeostatic capabilities in multiple endocrine systems. This book reviews advances in the understanding of endocrine facets of ageing. It considers the relative magnitudes and time courses of different endocrine adaptations in the ageing human and experimental animal, addressing the influence of external factors on the rates of progression of endocrine sequelae in ageing, the mechanisms that underlie the disarray of endocrine axes in ageing, and the implications of therapeutic reconstitution of hormones in ageing. This book:
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Contents
| 1 | |
| 26 | |
| 46 | |
| 66 | |
| 67 | |
| 82 | |
Veldhuis A Iranmanesh T Mulligan and C Y Bowers Mechanisms | 98 |
Zvi Laron Effects of growth hormone and insulinlike growth factor 1 deficiency | 125 |
Antonio RuizTorres The role of insulinlike growth factor 1 and insulin in ageing | 143 |
Henry G Burger Emma Dudley Pam Mamers David Robertson | 161 |
Holger Leitolf Jens Behrends and Georg Brabant The thyroid axis | 193 |
Dariush Elahi Denis C Muller Josephine M Egan Reubin Andres | 222 |
B Lawrence Riggs Endocrine causes of agerelated bone loss | 247 |
David Robertson Jens Jordan Giris Jacob Terry Ketch John R Shannon | 265 |
Veldhuis Summingup | 279 |
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Common terms and phrases
action activity adult ageing androgen animals appears associated axis blood body bone bone loss brain cause cells changes circulating Clin Endocrinol Metab clinical compared concentrations cortisol critical cycles decline decreased deficiency depression diabetes disease early effect elderly elevated endocrine et al evidence factors function GH secretion GHRH glucose growth hormone healthy human hypothalamic hypothyroidism IGF1 impaired important increased individuals infusion inhibin insulin Laron levels look lower male mass mean measured mechanisms menopause muscle normal observed occurs oestradiol oestrogen older ovulation patients perimenopause phase pituitary plasma population Prior production pulsatile pulse rats receptor reduced regulation relationship release remains replacement reported response risk role serum showed significant similar steroid stimulation stress studies subjects suggest syndrome testosterone thyroid tissue treatment Veldhuis Veldhuis JD women young
Popular passages
Page 259 - A unitary model for involutional osteoporosis: estrogen deficiency causes both type I and type II osteoporosis in postmenopausal women and contributes to bone loss in aging men.
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Page 137 - Increased mortality associated with growth hormone treatment in critically ill adults...
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Page 264 - Differential changes in bone mineral density of the appendicular and axial skeleton with aging : relationship to spinal osteoporosis.
Page 116 - Kojima, M., Hosoda, H., Date, Y, Nakazato, M., Matsuo, H., Kangawa, K.
Page 258 - Carani C, Qin K, Simoni M et al. Effect of testosterone and estradiol in a man with aromatase deficiency.
Page 14 - F (2000) Dehydroepiandrosterone (DHEA), DHEA sulfate, and aging: contribution of the DHEAge Study to a sociobiomedical issue.
References to this book
Menopause: The State of the Art- Research and Practice Hermann P.G. Schneider No preview available - 2002 |
Bibliographic information
| Title | Endocrine Facets of Ageing Volume 242 of Novartis Foundation Symposia |
| Editors | Derek J. Chadwick, Jamie A. Goode |
| Edition | illustrated |
| Publisher | John Wiley & Sons, 2002 |
| ISBN | 0471486361, 9780471486367 |
| Length | 296 pages |
| Subjects | › › Science / Life Sciences / Biology Science / Life Sciences / Biophysics |
| Export Citation | BiBTeX EndNote RefMan |