The Biochemical Basis of Neuropharmacology
This classic text gives a uniquely lucid and lively view of neurotransmitters, their role in nervous system function, and their involvement in the mechanisms of psychiatric drug action. For three decades it has served as an essential guide for students of neuroscience and psychopharmacology, residents in psychiatry and neurology, and clinicians and scientists. Both authoriative and very readable, it has been thoroughly updated for each edition. In the 8th Edition more space is devoted to clinical examples, subclasses of receptors that provide targets for new drugs, molecular genetics, the major problem of drug delivery to the brain, and the growing recognition of nicotin receptors in the brain and their possible involvement in Alxheimer's and Parkinson's diseases. In addition, the book's format has been enlarged and a second color added to many of the illustrations.
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Cellular Foundations of Neuropharmacology
Molecular Foundations of Neuropharmacology
Modulation of Synaptic Transmission
Amino Acid Transmitters
Norepinephrine and Epinephrine
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5-HT receptors acetylcholine action activity adenosine adenylyl cyclase agents agonists amino acid antagonists antipsychotic antipsychotic drugs autoreceptors axon behavioral binding biochemical block brain catecholamine cells cellular central ceptor choline cholinergic cloned concentration cortex cortical D2 receptors decrease depolarization disease disorders dopamine neurons dopamine receptors dopaminergic effects endogenous enzyme excitatory function GABA GABAA receptor gene glutamate H3 receptor hippocampus histamine hormone hydroxylase increase inhibition inhibitors interaction intracellular ion channels levels ligand locus ceruleus mammalian mechanisms mediated membrane metabolism MHPG modulation molecular molecules monoamine mRNA nerve terminal nervous system neurons neuropeptides neurotransmitter NMDA receptor noradrenergic norepinephrine nucleus opioid pathway peptide peripheral Pharmacol pharmacological phosphorylation physiological plasma postsynaptic potential presynaptic protein kinase protein-coupled recep receptor subtypes regulation release response reuptake role selective sequence serotonin specific stimulation structure studies substrate subunits synaptic synthesis tion tissue trans transmission transmitter transporter tryptophan tyrosine uptake vasopressin vesicles
Page 372 - Scahill L, Chappell PB, Kim YS, et al: A placebo-controlled study of guanfacine in the treatment of children with tic disorders and attention deficit hyperactivity disorder. Am J Psychiatry 158:1067-1074, 2001 Schechter MD, Timmons GD: Objectively measured hyperactivity, II: caffeine and amphetamine effects.