Nutraceuticals in Health and Disease Prevention

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Klaus Kramer, Peter-Paul Hoppe, Lester Packer
CRC Press, May 15, 2001 - Medical - 318 pages
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Promoting scientific support for the plethora of health benefits related to nutrition and medicine, Nutraceuticals in Health and Disease Prevention delivers a comprehensive and scientifically sound overview of the latest research findings in disease prevention, therapy, and enhanced body function in the revolutionary field of nutraceutical technology-with highlights from the Nutraceutical Conference held in Ludwigshafen, Germany.

Includes perspectives and reviews from recognized experts on nutraceuticals of scientific and public interest!

Recognizing the need to control the balance between environmental stressors and human health, Nutraceuticals in Health and Disease Prevention
  • presents developing areas of nutraceutical research with studies of effective examples
  • examines pathology treatments, including effects of S-adenosylmethionine (SAMe) on inflammatory disease and polyphenols on cardiovascular disease
  • investigates the role and benefits of vitamin E in aging and the antioxidant network
  • discusses the potency, multiple uses, and metabolic aspects of lipoic (thioctic) acid
  • reviews the second generation of carotenoid research and the disease prevention properties of lycopene and lutein
  • considers how polyunsaturated fatty acids (PUFAs) contribute to a healthy diet, from clinical and molecular perspectives
  • profiles the efficacy, safety, and use of creatine as an anabolic nutraceutical by athletes
  • analyzes identification methods for optimum delivery of nutrients, illustrated by the example of methyltetrahydrofolate
  • and much more!
    Containing over 1100 valuable literature references, drawings, and tables, Nutraceuticals in Health and Disease Prevention functions as an indispensable reference in the libraries of nutritionists and dietitians, pharmacists, molecular and cell biologists and biochemists, oncologists, endocrinologists, dermatologists, physiologists, epidemiologists, neurochemists, pediatricians, and upper-level undergraduate, graduate, and medical school students in these disciplines.
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    Contents

    Nutraceuticals The Link Between Nutrition and Medicine
    1
    The Role of Vitamin E in the Emerging Field of Nutraceuticals
    27
    SAdenosylmethionine SAMe Preclinical and Clinical Studies in Depression
    47
    SAdenosylLMethionine The Healthy Joint Product
    63
    Methyltetrahydrofolate The Superior Alternative to Folic Acid
    75
    Lycopene and Lutein The Next Steps to the Mixed Carotenoids
    91
    n3 Polyunsaturated Fatty Acids from Fish Effects on Coronary Artery Disease
    103
    Lipoic Acid A Multifunctional Nutraceutical
    113
    Creatine Physiology and Exercise Performance
    165
    Plant Phenols and Cardiovascular Disease Antioxidants and Modulators of Cell Response
    187
    LCarnitine and Its Precursor 𝛾Butyrobetaine
    217
    Conjugated Linoleic Acid
    257
    Contributions of Different Types of Evidence
    289
    The Brave New World of Foods That Make HealthRelated Claims
    293
    Index
    315
    Copyright

    R𝝰Lipoic Acid
    129

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    Page v - Free radicals can be overproduced or the natural antioxidant system defenses weakened, first resulting in oxidative stress, and then leading to oxidative injury and disease. Examples of this process include heart disease and cancer. Oxidation of human low-density lipoproteins is considered the first step in the progression and eventual development of atherosclerosis, leading to cardiovascular disease. Oxidative DNA damage initiates carcinogenesis. Compelling support for the involvement of free radicals...
    Page v - More and more evidence is accumulating that a proper balance between oxidants and antioxidants is involved in maintaining health and longevity, and that altering this balance in favor of oxidants may result in pathological responses causing functional disorders and disease.
    Page iv - ... necrosis). Virtually all diseases thus far examined involve free radicals. In most cases, free radicals are secondary to the disease process, but in some instances free radicals are causal. Thus, there is a delicate balance between oxidants and antioxidants in health and disease. Their proper balance is essential for ensuring healthy aging. The term oxidative stress indicates that the antioxidant status of cells and tissues is altered by exposure to oxidants. The redox status is thus dependent...
    Page iv - S) do not spontaneously form because sulfhydryl groups kept in the reduced state (SH) prevent protein misfolding or aggregation. This reducing environment is maintained by oxidative metabolism and by the action of antioxidant enzymes and substances, such as glutathione, thioredoxin, vitamins E and C, and enzymes such as superoxide dismutase (SOD), catalase, and the selenium-dependent glutathione and thioredoxin hydroperoxidases, which serve to remove reaction oxygen species.

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