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abnormalities acute hepatitis alcoholic hepatitis allograft alpha,-antitrypsin antigen Arch Pathol Lab associated bile ductular biliary atresia biliary obstruction biopsy specimens Budd-Chiari syndrome canalicular cholestasis cause central vein centrilobular characterized cholangiocarcinoma cholestasis cholestatic chronic active hepatitis chronic cholestasis chronic hepatitis Clin Pathol Clinical features copper cysts cytomegalovirus cytoplasmic develop dilatation disorders drug-induced drugs ductular proliferation ductules eosinophilic epithelial extrahepatic fatty change fibrous Figure focal Gostroenterol Gostroenterology granulomas hemochromatosis hepa hepatic injury hepatocellular carcinoma hepatocytes Hepatology histologic histologic features Hum Pathol hyperplasia infection inflammation involvement iron Ishak KG jaundice Kupffer cells lesions liver biopsy liver cells liver disease liver transplantation lobular lymphocytes Mallory bodies mild mononuclear morphologic necrosis neonatal neutrophils nodules nonspecific normal occasionally parenchymal pathogenesis patic patients Pediatr periportal portal tracts portal vein primary biliary cirrhosis primary sclerosing cholangitis prognosis Semin Liver serum sinusoidal stains steatohepatitis Surg therapy tion tissue tumor typically varying vascular viral hepatitis virus