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acid activity acute toxicity alcohol analysis animals aquatic assay benzo(a)pyrene bioaccumulation Biol biological blood cadmium cancer carcinogens cells Cent CHEM chemical chlorinated chromosome chronic compounds concentrations contamination culture cytochrome cytochrome P450 cytotoxicity decreased detection determined dioxin dose drug effects En;en En:en ENVIRON environmental enzyme ethanol evaluated excretion exposed female ﬁsh fumonisins genotoxicity Health heavy metals hepatic hepatocytes human hydrocarbons increased induced infection inhalation inhibition inst ISSN Japan kidney levels lipid liver lung lymphocytes macrophages male membrane mercury metabolism metabolites mg/kg mice monitoring mutagenicity MUTAT Natl observed occupational exposure organic oxide P.O. Box patients pesticides plasma pollution protein radiation rats respiratory response risk assessment samples serum signiﬁcant signiﬁcantly skin smoking species speciﬁc TCDD tion tissue toxicity toxicity testing TOXICOL toxin treatment tumor Univ Unlv uptake urine vitro vivo