Emerging technologies and new directions in drug abuse research
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A Mechanistic Basis for Design of Selective Agonists for 5HT
ComputerAided Drug Design for the Benzodiazepine
An Overview of a New Technique
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3D-searching 5-HT receptors 6-opioid 6-receptor affinity agonists amino acids antagonist approach assay atoms benzodiazepine receptors bilayer biochemical Biol cannabinoid characterization Chem chemical chemistry clinical cocaine complex compounds computational conformational criteria database dermorphin determined dopamine receptors DPDPE DPPC Drug Abuse drugs of abuse effects enkephalin enkephalin analogs figure function geometric GPO Stock Hruby hydrogen bonds Institute on Drug interaction inverse agonists investigation irreversible ligands ligands mechanism membranes methods molecular molecule NOEs nuclear magnetic resonance obtained opiate opioid peptides opioid receptor Osman percent BSA Ph.D Pharmacol pharmacological pharmacophore phencyclidine Photoaffinity labeling positron emission tomography potent probe Proc Natl Acad properties protein proton proton transfer Rapaka rat brain receptor ligands receptor selectivity recognition region Research residues resin Schiller side-chain simulations somatostatin specific spectra stock NTIS PB studies subtypes subunits synthesis tracer vitro vivo Weinstein