Chemical and Biological Aspects of Steroid ConjugationS. Bernstein, S. Solomon This book represents a collaborative endeavor by a group of investigators to bring together in a single volume a critical discussion of the major facets of our knowledge, ranging from chemical to clinical aspects, of steroid conjugation. However, the important field of bile acid and bile alcohol conjugation has been discussed only superficially since it was decided arbitrarily to be outside the projected scope of the book. The reader is referred to the companion volume of this book, namely Physical Properties of Steroid Conjugates (by Bernstein, Dusza, and Joseph, Springer-Verlag New York 1968), for complemental information on individual conjugates. The Editors wish to thank Miss Elise Kramer for typing assistance. Also we wish to express our deep appreciation and gratitude to Mrs. Dorothy Budd, our copy-editor, and Mr. J. Joseph for their editorial assistance in making this book possible. SEYMOUR BERNSTEIN Pearl River, N. Y. January, 1970 SAMUEL SOLOMON V11 CONTENTS Preface . . . . VII Nomenclature a, Discussion of Nomenclature System x b, Trivial and Systematic Names. x List of Contributors . . . . . . . . Xl Chemistry: Synthesis and Characterization S. BERNSTEIN, 1. P. DUSZA, and J. P. JOSEPH Enzymological Aspects of Steroid Conjugation A. B. Roy . . . . . . . . . . 74 The Hydrolysis of Steroid Conjugates H. L. BRADLOW . . . . . 131 Isolation of Steroid Conjugates P. K. SITTERI. . . . . . . 182 The Biochemistry of the 3P-Hydroxy-Ll5-Steroid Sulfates K. D. ROBERTS and S. LIEBERMAN 219 Formation, Metabolism, and Transport of Estrogen Conjugates E. DICZFALUSY and M. LEVITZ. . . . . . . . . . . . . |
Contents
SEYMOUR BERNSTEIN JOHN P DUSZA and JOSEPH P JOSEPH | 3 |
Sulfates | 25 |
Double Conjugates | 60 |
Copyright | |
11 other sections not shown
Other editions - View all
Chemical and Biological Aspects of Steroid Conjugation S. Bernstein,S. Solomon No preview available - 2012 |
Chemical and Biological Aspects of Steroid Conjugation Seymour Bernstein,Samuel Solomon No preview available - 1970 |
Common terms and phrases
17-ketosteroids 17ẞ-estradiol 3-sulfate acetate acid hydrolysis Acta Endocrinol ACTH activity administration of ACTH adrenal androstenedione androsterone androsterone sulfate assay Baulieu bile Biochem Biol Biophys C21-steroid CH3 CH Chem cholesterol cholesterol sulfate chromatography Clin compounds concentration conjugated equine estrogens corticosteroids cortisol dehydro dehydroiso dehydroisoandrosterone sulfate Diczfalusy doses Endocrinology enzyme ester estriol estriol-16-glucuronide estriol-3-sulfate estrogen conjugates estrogens estrone sulfate etiocholanolone excreted extraction fetal fetus Fishman formation fraction glucuronic acid glucuronide hormone human plasma Human urine hydrolysis hydrolyzed hydroxyl incubated inhibition injected intravenous investigators isolated Jayle labeled Levitz Lieberman liver Metab metabolism metabolites method methyl normal obtained oxidation Pasqualini patients placenta pregnancy pregnanediol pregnenolone pregnenolone sulfate preparations present procedure production progesterone pyridine radioactive reaction reported salt sodium solvent solvolysis ẞ-glucuronidase steroid conjugates steroid glucuronides steroid sulfates steroid sulfotransferases sterone studies substrate sulfatase sulfotransferases sulfurylation synthesis testosterone testosterone glucuronide tetrahydrocortisone tissues unconjugated urinary