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3ourn acid activity acute adult Age and Ageing age groups Amer animals assessment basal blood brain cancer cardiac cells cerebral cholesterol chromatin chronic clinical collagen concentration correlated cortisol cultures decline decrease dementia depression diagnosis differences digoxin disease disorders dose Drosophila Drosophila melanogaster drugs EFFECT OF AGE elderly patients entropion enzyme erythrocyte evaluation factors females fibroblasts flurazepam folate function Geria geriatric geriatric patients Geriatrics Soc Geront Gerontology glucose heart hepatic hormone hospital human hypertension impairment increased indicate Key Terms less levels lipid liver lymphocytes male measured membrane mental metabolism mice mortality mouse muscle myocardial infarction normal nursing home observed old rats older pattern percent plasma population protein proteoglycans psychiatric Rat Abstract response senescent senile serum sexual showed significant significantly skin stimulation subjects suggest syndrome synthesis testosterone therapy thyroid thyroxine tissue treatment urinary vitamin vitamin D vitro women young