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actinomycin action activity adenomas agents animals applied autogamy bacteria behaviour benign biological biotonic systems cancer capacity carcinogenic carcinoma characteristic characters chemical choriocarcinoma chromosomes ciliated clinical connective tissue cytoplasm depends described developmental differentiation discussion embryonic enzymes epidermal epithelial epithelium evidence experimental extrinsic factors facultative genome Foulds function genes genetic material genetic patterns gland Grobstein growth histological histone hormones hypothesis implanted important incipient neoplasia induced infective inferred invasion keratinizing lesions macronucleus malignant tumours mammary tumours mechanisms metagons metaplasia metastasis mice mitochondria mitosis morphogenesis mouse mutation neoplasia neoplastic neoplastic cells neoplastic development neuroblastoma normal nucleic acid nucleus observations operon organization organoid papillomas paramutation parent tissue phenotypic plaques pregnancy preselection primary tumour probably processes progression proliferation protein synthesis regression response Rous seems skin specific spontaneous stage stimulus strain stroma structure teratogenic teratomas tion total genome transcription transplanted tumours trophoblast tubules tumour cells tumours urethane virus viruses vitro