Toxic Phosphorus Esters: Chemistry, Metabolism, and Biological Effects

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Elsevier, Jul 29, 2016 - Science - 446 pages
Toxic Phosphorus Esters: Chemistry, Metabolism, and Biological Effects aims to become a source book on organophosphate research and show how the understanding of the events following organophosphate poisoning of animals can be understood in terms of events at the molecular level.
The manuscript first offers information on nonenzymic reactions and the reaction with cholinesterase in vitro. Discussions focus on hydrolysis, isomerization, oxidation, phosphorylation of the enzyme, and selectivity for different cholinesterases. The text then examines enzymic degradation and activation in vitro, effects in mammals, and effects on isolated whole tissues.
The publication ponders on the effects in insects and plants, including results of poisoning, metabolism, resistance, antagonism and synergism, and phytotoxicity. The text also reviews selective toxicity, as well as excretion and storage, metabolism, design of new selective compounds, and nature of the target.
The manuscript is a dependable reference for readers interested in the composition, reactions, and effects of toxic phosphorus esters.
 

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Contents

Chapter 1 Introduction
1
Chapter 2 Nonenzymic Reactions
29
Chapter 3 The Reaction with Cholinesterase in Vitro
73
Chapter 4 Enzymic Degradation and Activation in Vitro
115
Chapter 5 Effects on Isolated Whole Tissues
149
Chapter 6 Effects in Mammals
175
Chapter 7 Effects in Insects
241
Chapter 8 Effects in Plants
289
Chapter 9 Selective Toxicity
315
Chapter 10 Techniques
345
Electronic Interpretations
381
Structure of Organophosphates
391
AUTHOR INDEX
401
SUBJECT INDEX
415
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