Biochemistry of PlateletsDavid Phillips Biochemistry of Platelets is a comprehensive review of the biochemistry of platelets, with emphasis on the molecular basis for the various biological processes in which they participate. Topics range from stimulus-response coupling mechanisms to platelet contractile proteins, platelet membrane glycoproteins, and storage organelles in platelets and megakaryocytes. The expression and function of adhesive proteins on the platelet surface is also discussed. Comprised of 12 chapters, this book begins with a description of the morphological and metabolic responses to agonists, as well as the involvement of certain processes in the coupling of agonist-receptor interactions to platelet responses. The following chapter deals with platelet arachidonate metabolism and platelet-activating factor, focusing on the release of arachidonate from platelet lipid stores; pathways of platelet arachidonate metabolism and effects of arachidonate metabolites; and inhibition of platelet arachidonate metabolism by aspirin. The structure, function, and modification in disease of platelet membrane glycoproteins are then discussed, along with prothrombin activation on platelets and platelet regulation of thrombus formation. Secreted platelet proteins as markers for pathological disorders are also considered. This monograph is intended as a reference for investigators involved in platelet research as well as a source of information for those working in other areas of biological investigation. |
Contents
| 1 | |
Chapter 2 Platelet Arachidonate Metabolism and PlateletActivating Factor
| 69 |
Chapter 3 Platelet Contractile Proteins
| 115 |
Their Structure Function and Modification in Disease
| 159 |
Chapter 5 Expression and Function of Adhesive Proteins on the Platelet Surface
| 225 |
Chapter 6 Storage Organelles in Platelets and Megakaryocytes
| 257 |
Prothrombin Activation on Platelets
| 295 |
Chapter 8 Platelet Regulation of Thombus Formation
| 319 |
Purification Characterizationand Role in Normal and Abnormal Cell Growth
| 347 |
Chapter 10 Secreted Platelet Proteins as
Markers for Pathological Disorders | 377 |
Chapter 11 Megakaryocyte Biochemistry
| 417 |
Chapter 12 Future Directions in Platelet Research | 443 |
| 453 | |
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Common terms and phrases
Acad acid actin actin filaments actin-binding protein activated platelets adenylate cyclase adhesive proteins agonists antibodies antigen arachidonate B-TG B-thromboglobulin Bemard—Soulier Biochem Biophys blood platelets Ca2+ calcium cell surface Chem Clin clotting coagulation collagen concentrations cyclooxygenase demonstrated diglyceride effect enzyme factor Va factor Xa factor XIIIa fibrinogen fibronectin filaments Ginsberg GP Ib GP Ilb—Illa GP Illa Haematol human platelets induced inhibition inhibitors inositol interaction intracellular ionophore isolated Levine light chain Majerus mechanism megakaryocytes metabolism myosin Natl Nature London normal Nurden pathway patients PDGF Phillips phosphatidylinositol phospholipid phosphorylation plasma membrane platelet activation platelet aggregation platelet factor platelet function platelet membrane glycoproteins platelet proteins platelet secretion platelet surface platelet-derived growth factor polymerization Proc prostacyclin prostaglandin protease protein kinase prothrombin PtdIns purified reaction receptor release response role specific stimulation studies syndrome synthesis Thromb thrombasthenia thrombin thrombin-induced thrombospondin thromboxane tion unstimulated platelets vitro von Willebrand factor Willebrand factor