Chemically Induced Cell Proliferation: Implications for Risk Assessment
Byron Butterworth, Thomas J. Slaga, William Farland, R. Michael McClain
John Wiley & Sons, Jul 30, 1991 - Medical - 582 pages
Written by leaders in their respective fields, it provides current information on various roles that chemically induced cell proliferation might play in the carcinogenic process. With today's intense economic competiton, limited environmental resources and conflicting advice to the public on personal dangers, cancer policy needs to be based on the best available information. The association of chemically induced cell proliferation with carcinogenic activity is so prevalent that it must be considered in evaluating the carcinogenic danger of chemicals to which people may be exposed. The overviews offer insights into these mechanisms that should yield new predictive assays, improved design and interpretation for cancer bioassays and more realistic risk evaluations.
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3H]thymidine acid activity adducts administration agents altered animals apoptosis AsA-Na assay basal cells bioassay Biochem bladder BrdU Cancer Res carcinogenesis carcinogens carcinoma cell death cell proliferation cell replication cellular chemically induced cell chronic clonogens crypt cultures DEHP diet differentiation DNA synthesis dose effects enzyme epidermal epithelial cells epithelium estrogen exposure female foci forestomach formaldehyde gavage genotoxic growth factor hamster hepatectomy hepatic hepatocarcinogenesis human hyperplasia increase induced cell proliferation inhibition initiated cells keratinocytes kidney kinetics labeling index lesions levels liver male rats mechanisms mg/kg mice mitogenesis mitogenic mitotic mouse mucosa mutagens mutations nasal neoplastic normal oncogenes peroxisome peroxisome proliferation phenobarbital preneoplastic proliferative protein rat liver rats treated receptor regeneration renal respiratory response Risk Assessment rodent Schulte-Hermann stem cells stimulation studies thyroid tissue toxicity Toxicol Toxicology treatment tumor promoters urinary urinary bladder vitro vivo weeks