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SCIENTIFIC BASIS FOR THE STUDY OF
CLINICAL ASPECTS AND TREATMENT
AUTOANTIBODIES IN SYSTEMIC LUPUS ERYTHEMATOSUS
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abnormalities activity acute agents amyloid amyloidosis anti antibodies anticoagulant antigen appear arteries Arthritis Rheum associated autoantibodies autoimmune biopsy blood body bone cause cells changes chronic Clin clinical common complexes connective tissue disease corticosteroids creatine cutaneous cytoplasmic deposits dermatomyositis described detected develop diagnosis diffuse disorders doses early effects elevated et al evidence factor fibromyalgia FIGURE findings frequently function heart human immune Immunol increased infection infiltrates inflammatory initial Intern involvement joint lesions less levels loss lymphocytes major manifestations MCTD mechanisms Medicine mixed muscle myositis normal noted observed occur organ pain patients polymyositis present primary production progressive protein pulmonary rare renal reported response result rheumatic fever Rheumatol scleroderma seen serum severe Sjögren's syndrome skin specific suggest symptoms syndrome systemic lupus erythematosus systemic sclerosis Table therapy tients tion treated treatment usually vasculitis vessels