Fitting Models to Biological Data Using Linear and Nonlinear Regression: A Practical Guide to Curve FittingMost biologists use nonlinear regression more than any other statistical technique, but there are very few places to learn about curve-fitting. This book, by the author of the very successful Intuitive Biostatistics, addresses this relatively focused need of an extraordinarily broad range of scientists. |
Contents
| 12 | |
| 13 | |
B Fitting data with linear regression | 47 |
C Models | 58 |
D How nonlinear regression works | 80 |
E Confidence intervals of the parameters | 97 |
F Comparing models | 134 |
G How does a treatment change the curve? | 160 |
H Fitting radioligand and enzyme kinetics data | 187 |
I Fitting doseresponse curves | 256 |
J Fitting curves with GraphPad Prism | 296 |
| 348 | |
| 350 | |
Other editions - View all
Fitting Models to Biological Data Using Linear and Nonlinear Regression: A ... Harvey Motulsky No preview available - 2004 |
Common terms and phrases
affinity AICc analysis analyze ANOVA antagonist assumption best-fit curve best-fit value binding curve binding data Bmax bottom plateau calculations chapter choose column compare models competitive binding compute concentration of radioligand confidence interval constant value constrain curve fitting data points data sets define degrees of freedom Deming regression determine dialog dissociation dose dose-response curve drug enter enzyme kinetics equal example experimental exponential decay F test fit the data fraction Gaussian distribution global fitting graph Hill slope HillSlope homologous competition initial values kinetics koff labeled ligand ligand linear regression logarithm logEC50 mean method nonlinear regression program nonspecific binding null hypothesis number of data number of parameters one-site Prism radioactivity radioligand binding rate constant receptor regression line replicates response saturation binding Scatchard plot scatter sigmoid dose-response slope factor specific binding standard curve standard errors statistical substrate sum-of-squares total binding two-site unlabeled variable Vmax weighting zero