Chemistry and Pharmacology
Academic Press, Aug 31, 1995 - Medical - 364 pages
Internationally acclaimed for more than forty years, this serial, founded by the late Professor R.H.F. Manske, continues to provide outstanding coverage of the rapidly expanding field of the chemotaxonomy, structureelucidation, synthesis, biosynthesis, and biology of all classes of alkaloids from higher and lower plants, marine organisms, or various terrestrial animals. Each volume provides, through its distinguished authors, up-to-date and detailed coverage of particular classes or sources of alkaloids. Over the years, this series has become the standard in natural product chemistry to which all other book series aspire. The Alkaloids: Chemistry and Pharmacology endures as an essential reference for all natural product chemists and biologists who have an interest in alkaloids, their diversity, and their unique biological profile.
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Chapter 2 Pharmacology of Polyamine Toxins from Spiders and Wasps
Chapter 3 Epibatidine
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abbreviatus absolute configuration acid amino analogs ancistrobrevine Ancistrocladaceae ancistrocladine 1a Ancistrocladus atropisomer axis benzophenanthridines berberine Berberine 17 biaryl Biological activity biosynthesis Bringmann cadaverine CHCl chelerythrine chelidonine Chem chiral CO2H compounds Corydalis coupling D. J. Robins degradation derivative dihydrochloride dihydrosanguinarine dimeric Dioncophyllaceae dioncophylline A 14a enantiomer enzyme epibatidine feeding experiments glutamate H-NMR heyneanus homospermidine hydroxylation incisa incorporation intermediate isolated isomer isoquinoline korupensamine korupensis labeling patterns lupinine MeO OMe methyl michellamines molecules N-metho N-methyl naphthalene naphthylisoquinoline alkaloids natural product necines NMDA receptors o-N-metho salt obtained OCH.O OCH2O OMe OMe OMe ophiocarpa oxidation oxygen function pathway peltatum Perkin Trans Phytochemistry plants polyamine toxins potent precursor produce protoberberines protopine putrescine quinolizidine quinolizidine alkaloids reaction retronecine retrorsine ring sanguinarine Scheme scoulerine Section Senecio sparteine species Spectroscopy spider stem bark stereocenters stereochemical stereochemistry stereoselective Structure Elucidation substituent substrate synthetic Table tetrahydroprotoberberines total synthesis triphyophylline unpublished results venom