Pharmacokinetics for the Pharmaceutical ScientistMajor presentation of pharmacokinetics by a leading international expert. Methods for: estimating drug disposition parameters from data obtained after intravascular or extravascular drug administration, estimating rate and extent of drug bioavailability, and comparing rate and extent of drug availability following administration of several different dosage forms of a drug. |
Contents
Chapter 1 Simple Linear Models | 1 |
Chapter 2 More Complicated Linear Models | 15 |
Chapter 3 Complicated Linear Models | 45 |
Chapter 4 Linear Multicompartment Disposition Parameters from Downslope Extravascular Ct Data | 63 |
Chapter 5 Noncompartmental and System Analysis | 83 |
Chapter 6 Linear Multiple Dose Equations | 103 |
Chapter 7 Simple Nonlinear Models | 111 |
Chapter 8 More Complicated Nonlinear Models | 143 |
Chapter 12 Relationship between Physiologically Based Flow Models and Usual Compartment Models | 225 |
Chapter 13 Protein Binding | 243 |
Chapter 14 PharmacokineticPharmacodynamic Modelling | 259 |
Chapter 15 Metabolic Kinetics | 269 |
Chapter 16 Laplace Derivation of Linear Pharmacokinetic Equations | 281 |
Chapter 17 Measures of Fit | 293 |
Appendix | 299 |
| 305 | |
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Common terms and phrases
A₁ adinazolam amount of drug applied AUC 0-Inf biexponential Equation bioavailability bolus bolus intravenous C₁ CBSS central compartment cimetidine CLpo CLSS coefficients CONCENTRATION µg/ml curve deconvolution diazepam differential equations digoxin diphenhydramine disposition parameters drug concentration elimination rate constant Equa estimated parameters Exact Loo-Riegelman example excretion fitted to Equation flunarizine flurbiprofen given by Equation gives Equation Hence HOURS hr¯¹ hr¹ Intrasubject C.V. k₁ kinetics L/min labetalol Laplace transforms least squares linear liver mean metabolism metabolite Method IIIA mg/L mg/ml MICHAELIS-MENTEN ELIMINATION MINSQ Model VIII Model XXXIX ng/ml obtained ONE-COMPARTMENT OPEN MODEL penicillamine pharmacokinetic plasma concentrations plot prednisolone prednisone R₁ rate constant renal clearance RLVL SCHEME serum shown in Figure simulated single dose single-dose slope spectinomycin steady Table tion tissue TWO-COMPARTMENT OPEN MODEL Verapamil versus volume of distribution Wagner warfarin zero zero-order input λ₁ λ₂ λι