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INTRINSIC NEURONAL LIMITATIONS TO REGENERATION _
RATIONALE AND HYPOTHESES
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actin actin bundles adult rat aggrecan aggrecan substrates antibody axonal growth axonal regeneration BDNF brainstem brainstem-spinal neurons brainstem-spinal populations cell bodies chick chondroitin sulfate proteoglycan CNS neurons cofilin corticospinal corticospinal tract CSPG cultures cytoskeleton Dil-labeled DRG neurite DRG neurons effects embryonic environment explant cultures explants containing factors filopodia gene glial grown on inhibitory growth capacity growth cone growth cone collapse growth inhibition GTPases inhibitory molecules inhibitory substrates intracellular signaling Jin and Strittmatter kinase labeled lamellipodia laminin lesion mediated myelin myelin-associated glycoprotein neurite growth neuronal populations Neurosci neurotrophins Nogo peripheral nerve permissive phosphorylation promote axonal promoted neurite outgrowth protein raphe explants raphe-spinal neurons rat spinal cord receptor Red nucleus regeneration failure regrowth Rho activity Rho-GTPases ROCK activity scar Schwab M. E. Schwann cell serotonergic signaling pathways spinal cord injury Steeves J. D. substrates supraspinal target Tetzlaff thesis total outgrowth treatment ug/ml vestibular explants vitro vivo