Intrinsic Neuronal Determinants of Neurite RegrowthUniversity of British Columbia (Canada), 2002 - 280 pages |
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Page 63
... embryonic ages . Although the growth from older embryonic raphe - spinal explants is less than that of younger embryonic neurons , raphe - spinal neurons retain an enhanced capacity for growth at later ages compared to the four other ...
... embryonic ages . Although the growth from older embryonic raphe - spinal explants is less than that of younger embryonic neurons , raphe - spinal neurons retain an enhanced capacity for growth at later ages compared to the four other ...
Page 102
... embryonic vs. adult neurons , and this may contribute to regeneration failure in the adult CNS . In complement to the upregulated expression of receptors to inhibitory molecules , the down - regulation of appropriate receptors to ...
... embryonic vs. adult neurons , and this may contribute to regeneration failure in the adult CNS . In complement to the upregulated expression of receptors to inhibitory molecules , the down - regulation of appropriate receptors to ...
Page 103
... embryonic neurons , but had no effect on adult neurons . Interestingly , both adult and embryonic neurons express ẞl - integrin receptors , suggesting that adult neurons have lost ẞl signaling fimction , possibly due to the down ...
... embryonic neurons , but had no effect on adult neurons . Interestingly , both adult and embryonic neurons express ẞl - integrin receptors , suggesting that adult neurons have lost ẞl signaling fimction , possibly due to the down ...
Contents
EXTRINSIC CNS ENVIRONMENTAL LIMITATIONS TO REGENERATION | 4 |
AXONAL GROWTH AND RHOGTPases | 11 |
RATIONALE AND HYPOTHESES | 24 |
1 other sections not shown
Common terms and phrases
actin actin bundles actin cytoskeleton adult rat aggrecan aggrecan substrates antibody axonal growth axonal regeneration BDNF brainstem brainstem-spinal neurons cell bodies chick chondroitin sulfate proteoglycan CNS neurons cofilin corticospinal corticospinal tract CSPG cultures cytoskeleton Dil-labeled DRG neurite DRG neurons effects embryonic environment explant cultures explants containing factors filopodia gene glial grown on inhibitory growth capacity growth cone growth cone collapse growth inhibition GTPases induced inhibitory molecules inhibitory substrates intracellular signaling intrinsic neuronal Journal of Neuroscience kinase labeled lamellipodia laminin lesion mediated myelin myelin-associated glycoprotein neurite growth Neurosci neurotrophins Nogo peripheral nerve permissive phosphorylation promote axonal promoted neurite outgrowth protein raphe explants raphe-spinal neurons rat spinal cord receptor Red nucleus regeneration failure regrowth Rho-GTPases Rho-kinase ROCK activity ROCK inhibition scar Schwab M. E. semaphorin serotonergic signaling pathways spinal cord injury Steeves J. D. Tetzlaff thesis total outgrowth treatment vestibular explants vitro vivo µg/ml