Intrinsic Neuronal Determinants of Neurite RegrowthUniversity of British Columbia (Canada), 2002 - 280 pages |
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Page 19
... mediated by its binding with downstream protein kinase effectors ( Fig . 1-2 ) . The effectors bind to Rho on a short effector loop domain that becomes exposed during Rho - GTP binding ( Bishop and Hall , 2000 ) . The most well ...
... mediated by its binding with downstream protein kinase effectors ( Fig . 1-2 ) . The effectors bind to Rho on a short effector loop domain that becomes exposed during Rho - GTP binding ( Bishop and Hall , 2000 ) . The most well ...
Page 66
... mediated primarily through the action of the Rho family of small guanosine triphosphatases ( GTPases ) on the actin cytoskeleton ( Luo , 2000 ) . In non - neuronal cells , activation of Rac and Cdc42 induces the formation of ...
... mediated primarily through the action of the Rho family of small guanosine triphosphatases ( GTPases ) on the actin cytoskeleton ( Luo , 2000 ) . In non - neuronal cells , activation of Rac and Cdc42 induces the formation of ...
Page 130
... mediated axonal guidance via Rho - related G proteins . Curr Opin Cell Biol 13 ( 5 ) : 619-626 . Liu B. P. ... mediate regenerative versus developmental sensory axon growth . J Neurosci 21 ( 17 ) : RC164 . Lund S. , Pompeiano O. ( 1968 ) ...
... mediated axonal guidance via Rho - related G proteins . Curr Opin Cell Biol 13 ( 5 ) : 619-626 . Liu B. P. ... mediate regenerative versus developmental sensory axon growth . J Neurosci 21 ( 17 ) : RC164 . Lund S. , Pompeiano O. ( 1968 ) ...
Contents
EXTRINSIC CNS ENVIRONMENTAL LIMITATIONS TO REGENERATION | 4 |
AXONAL GROWTH AND RHOGTPases | 11 |
RATIONALE AND HYPOTHESES | 24 |
1 other sections not shown
Common terms and phrases
actin actin bundles actin cytoskeleton adult rat aggrecan aggrecan substrates antibody axonal growth axonal regeneration BDNF brainstem brainstem-spinal neurons cell bodies chick chondroitin sulfate proteoglycan CNS neurons cofilin corticospinal corticospinal tract CSPG cultures cytoskeleton Dil-labeled DRG neurite DRG neurons effects embryonic environment explant cultures explants containing factors filopodia gene glial grown on inhibitory growth capacity growth cone growth cone collapse growth inhibition GTPases induced inhibitory molecules inhibitory substrates intracellular signaling intrinsic neuronal Journal of Neuroscience kinase labeled lamellipodia laminin lesion mediated myelin myelin-associated glycoprotein neurite growth Neurosci neurotrophins Nogo peripheral nerve permissive phosphorylation promote axonal promoted neurite outgrowth protein raphe explants raphe-spinal neurons rat spinal cord receptor Red nucleus regeneration failure regrowth Rho-GTPases Rho-kinase ROCK activity ROCK inhibition scar Schwab M. E. semaphorin serotonergic signaling pathways spinal cord injury Steeves J. D. Tetzlaff thesis total outgrowth treatment vestibular explants vitro vivo µg/ml