Intrinsic Neuronal Determinants of Neurite RegrowthUniversity of British Columbia (Canada), 2002 - 280 pages |
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Page 4
... myelin ; and 2 ) the formation after injury of a glial scar containing many inhibitory molecules . Myelin in White Matter Tracks Inhibits Axonal Growth The best characterized example of a CNS axonal inhibitor is myelin . It is currently ...
... myelin ; and 2 ) the formation after injury of a glial scar containing many inhibitory molecules . Myelin in White Matter Tracks Inhibits Axonal Growth The best characterized example of a CNS axonal inhibitor is myelin . It is currently ...
Page 5
... myelin inhibition in its entirety , is the immunological removal of myelin by the application of serum complement and an antibody to galactocerebroside . This method has promoted the growth of descending axons in the injured spinal ...
... myelin inhibition in its entirety , is the immunological removal of myelin by the application of serum complement and an antibody to galactocerebroside . This method has promoted the growth of descending axons in the injured spinal ...
Page 68
... Myelin Substrates To challenge regenerating axons with more complex inhibitory environments , myelin membrane fractions and adult rat spinal cord were used as growth substrates for E15 chick DRG in identical media conditions as ...
... Myelin Substrates To challenge regenerating axons with more complex inhibitory environments , myelin membrane fractions and adult rat spinal cord were used as growth substrates for E15 chick DRG in identical media conditions as ...
Contents
EXTRINSIC CNS ENVIRONMENTAL LIMITATIONS TO REGENERATION | 4 |
AXONAL GROWTH AND RHOGTPases | 11 |
RATIONALE AND HYPOTHESES | 24 |
1 other sections not shown
Common terms and phrases
actin actin bundles actin cytoskeleton adult rat aggrecan aggrecan substrates antibody axonal growth axonal regeneration BDNF brainstem brainstem-spinal neurons cell bodies chick chondroitin sulfate proteoglycan CNS neurons cofilin corticospinal corticospinal tract CSPG cultures cytoskeleton Dil-labeled DRG neurite DRG neurons effects embryonic environment explant cultures explants containing factors filopodia gene glial grown on inhibitory growth capacity growth cone growth cone collapse growth inhibition GTPases induced inhibitory molecules inhibitory substrates intracellular signaling intrinsic neuronal Journal of Neuroscience kinase labeled lamellipodia laminin lesion mediated myelin myelin-associated glycoprotein neurite growth Neurosci neurotrophins Nogo peripheral nerve permissive phosphorylation promote axonal promoted neurite outgrowth protein raphe explants raphe-spinal neurons rat spinal cord receptor Red nucleus regeneration failure regrowth Rho-GTPases Rho-kinase ROCK activity ROCK inhibition scar Schwab M. E. semaphorin serotonergic signaling pathways spinal cord injury Steeves J. D. Tetzlaff thesis total outgrowth treatment vestibular explants vitro vivo µg/ml