Organic Stereochemistry: Experimental and Computational Methods
Adopting a novel approach to the topic by combining theoretical knowledge and practical results, this book presents the most popular and useful computational and experimental methods applied for studying the stereochemistry of chemical reactions and compounds.
The text is clearly divided into three sections on fundamentals, spectroscopic and computational techniques, and applications in organic synthesis. The first part provides a brief introduction to the field of chirality and stereochemistry, while the second part covers the different methodologies, such as optical rotation, electronic circular dichroism, vibrational circular dicroism, and Raman spectroscopy. The third section then goes on to describe selective examples in organic synthesis, classified by reaction type, i.e. enantioselective, chemoselective and stereoselective reactions. A final chapter on total synthesis of natural products rounds off the book.
A valuable reference for researchers in academia and industry working in the field of organic synthesis, computational chemistry, spectroscopy or medicinal chemistry.
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Nonoptical Method in Configuration Study
Electronic Circular Dichroism
Vibrational Circular Dichroism and Raman Optical Activity
Combinational Use of Different Methods
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13C NMR 1H NMR AC assignment acid afford alcohol aldehydes amine Angew atom barrier basis set bioactive bond Calcd calculated carbon catalyst catalyzed Chem chemoselective chiral catalysts chiral compounds chiral molecule chromophore circular dichroism computed configuration corresponding Cotton effect det(D diastereoselective diethylzinc ee values electronic enantiomers enantioselective Entry equiv ester example exciton Exp ECD experimental ECD Figure formation geometries H OH i-Pr intermediate kcal kcal mol−1 ketone KGaA methods molecular Mosher natural products OH O OH OH OH optical Organic Stereochemistry oxidation Ph Ph phenyl Phys polarized predicted procedure quantum reaction reagent reduction regioselective rotation S)-Mosher Scheme solvent stable conformations stereochemistry stereogenic center structure substituents substrates Table TBSO temperature Tetrahedron Lett theoretical total synthesis VCD spectra Wang Wavelength Wavelength nm Wavenumber Wavenumber cm−1 Wiley-VCH Verlag yield Zhang