A Genetic Switch: Phage Lambda Revisited

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CSHL Press, 2004 - Science - 154 pages
3 Reviews
The first edition of Mark Ptashne's 1986 book describing the principles of gene regulation in phage lambda became a classic in both content and form, setting a standard of clarity and precise prose that has rarely been bettered. This edition is a reprint of the original text, together with a new chapter updating the story to 2004. Among the striking new developments are recent findings on longā€“range interactions between proteins bound to widely separated sites on the phage genome, and a detailed description of how gene activation works.
 

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Contents

CHAPTER
4
THE MASTERELEMENTS OF CONTROL
14
CHAPTER
31
CHAPTER THREE
47
Other Phages
60
CHAPTER FOUR
67
Repressor Isolation and DNA Binding
72
A repressor dimer binds through its amino domains to a 17 base pair
78
There are three 17 base pair repressor binding sites in the right operator
84
Cro binds first to O3 then to O 1 and O2 thereby first turning off
92
CHAPTER FIVE
109
Index
151
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Epigenetics
C. David Allis
Limited preview - 2007
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