A Genetic Switch: Phage Lambda Revisited

Front Cover
CSHL Press, 2004 - Medical - 154 pages
3 Reviews
The first edition of Mark Ptashne's 1986 book describing the principles of gene regulation in phage lambda became a classic in both content and form, setting a standard of clarity and precise prose that has rarely been bettered. This edition is a reprint of the original text, together with a new chapter updating the story to 2004. Among the striking new developments are recent findings on longā€“range interactions between proteins bound to widely separated sites on the phage genome, and a detailed description of how gene activation works.
 

What people are saying - Write a review

We haven't found any reviews in the usual places.

Contents

CHAPTER
4
THE MASTERELEMENTS OF CONTROL
14
CHAPTER
31
CHAPTER THREE
47
Other Phages
60
CHAPTER FOUR
67
Repressor Isolation and DNA Binding
72
A repressor dimer binds through its amino domains to a 17 base pair
78
There are three 17 base pair repressor binding sites in the right operator
84
Cro binds first to O3 then to O 1 and O2 thereby first turning off
92
CHAPTER FIVE
109
Index
151
Copyright

Other editions - View all

Common terms and phrases

Popular passages

Page 141 - Other examples of the contribution of secondary products to chemosystematics can be found in the references cited at the end of the chapter but this is an area in which there is great scope for further research.
Page 147 - RIGGS. 1975. The general affinity of lac repressor for E. coli DNA: Implications for gene regulation in prokaryotes and eukaryotes. Cell 4: 107.
Page 105 - Ingles. 1985. Extensive homology among the largest subunits of eukaryotic and prokaryotic RNA polymerases. Cell 42:599-610.
Page 106 - Meyer BJ, Maurer R., and Ptashne M. 1980. Gene regulation at the right operator (OR) of bacteriophage lambda.
Page 105 - DNase footprinting: a simple method for the detection of protein-DNA binding specificity. Nucl. Acids. Res.
Page 137 - DL (2001). Bacteriophage lambda: Alive and well and still doing its thing. Curr. Opin. Microbiol 4, 201-207. 2. Hendrix, RW, Roberts, JW, Stahl, JW, and Weisberg, RA (Eds.) (1983). Lambda II. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY. 3. Ptashne, M. (1992). "A Genetic Switch,
Page 29 - R. 1983. Represser and Cro protein: Structure, function, and role in lysogenization. In Lambda II, ed.
Page 105 - Maximizing gene expression on a plasmid using recombination in vitro.
Page 106 - CALEF, 1970 Immunity phase-shift in defective lysogens: non-mutational hereditary change of early regulation of X prophage.
Page 46 - Siebenlist U., Simpson RB, and Gilbert W. 1980. E. coli RNA polymerase interacts homologously with two different promoters. Cell 20: 269-281.

References to this book

Epigenetics
C. David Allis
Limited preview - 2007
All Book Search results »

Bibliographic information