Kinins

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Michael Bader
Walter de Gruyter, Nov 30, 2011 - Science - 386 pages
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This handbook of kinin biology and biochemistry covers the current knowledgeof kinins, a family of peptides involved in numerous physiological and pathophysiological processes. Recent publications have shown that the kinin system is highly relevant in a variety of disease states such as diabetes, multiple sclerosis and traumatic injuries. Furthermore, the first drug targeting system has just been approved for clinical use. The goal of this book is to provide advanced students and researchers a basic understanding of the kinin system and its role within the various organ systems.

The authors of this book are experts in their fields, including a Nobel Laureate.

 

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Contents

History and outlook
1
2 Molecular and genetic aspects of the kallikreinkinin system
7
3 Kinin receptor signaling and regulation
33
4 Animal models in the kinin field
51
5 Drugs in the kallikreinkinin system
69
6 Kallikreinkinin system in the brain
85
7 The role of the renal kallikreinkinin system in physiology and pathology
103
8 Kallikreinkinin system in the heart
117
12 Kallikreinkinin system in reproductive organs
187
13 The Kallikreinkinin system and thrombosis
203
kallikreins and kinins in cancer
217
15 Kallikreinkinin system in pain
247
16 Kallikreinkinin system in inflammation
261
17 Kallikreinkinin system in diabetes
273
18 Kallikreinkinin system in angioedema
289
19 Kinins in bacterial infections
307

9 Kallikreinkinin system in the vessel wall
137
modulators of skin homeostasis
155
11 Kallikreinkinin system in the eye
171
20 The kallikreinkinin system in parasitic infections
321
21 Kallikreinkinin system in ischemic stroke and brain trauma
337
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About the author (2011)

Michael Bader, Max Delbrück Center for Molecular Medicine, Berlin, Germany.

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