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NUMBER 9 JUNE 10 1998
Immunization with Both T CellDependent and T CellIndependent Vaccines Augments
Neutralizing Antibodies Directed against the V3 Loop Select for Different Escape Variants in
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activity addition AIDS amino acid analysis animals antibodies antigen assay base binding blood CD4+ cells Center changes clade clinical clones compared concentration containing cultures described detected determined dilution disease DPP-IV drug effect envelope epitopes expression gene genetic HIV-1 infection human immunodeficiency virus immune immunodeficiency virus type increase indicated individuals induced infection inhibition inhibitors Institute isolates Laboratory levels lymphocytes macaques male mean Medical method mice months mutations Nature neutralizing observed obtained patients PBMCs peptide performed plasma positive present primer production protein reference region replication reported Research resistance response Retroviruses reverse samples selected sequences sera serum showed shown similar specific strains subtype suggest Table tested therapy tion titers treated treatment University V3 loop vaccine values viral Virol viruses weeks Western blot