Minoru Fukuda, Ole Hindsgaul
IRL Press, 1994 - Carbohydrates. - 261 pages
Cell Surface carbohydrates play critical roles in cell-cell interaction. In recent years, amjor advances have been made in understanding the molecular mechanisms of these processes. Genes encoding glycosyltransferases that synthesise unique obligosccharides have been isolates, allowing the correlation of specific oligosccharide structures with function. This book brings together leading researchers to describe our current knowledge in this important area of modern biology. Particularemphasis is given to cell type specific carbohydrate expression and the carbohydrates and proteins involved in cell recognition. Also included is a full discussion of key experimental approaches such as chemical synthesis and the three dimensional structural analysis of carbohydrates. Molecular Glycobiologyis a timely synopsis of this exciting and rapidly expanding file. It provides both an up to date description of the subject and leading researchers view of likely future developments. Assuch, this volume will be invaluable for active researchers in glycobiology and medicine. However, its easily readable style will aso appeal to non specialists who need an authoritative but accessible text on this subject.
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Celltype specific expression of ATglycans
Mucintype glycans Oglycans
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a2,6-sialyltransferase a3-Fuc-transferase a3-Gal-transferase acceptor activity adhesion molecule affinity amino acid amino acid sequences analysis animal lectins antibody antigen asialoglycoprotein binding Biochem Biol biosynthesis bovine C-type C-type CRDs carbohydrate cDNA encoding cell adhesion cell line cell surface Chem chromosome cloned coding region complex conformation contain core cytoplasmic E-selectin endothelial cells endothelium enzyme epitopes erythrocytes exons expression Figure Fuc-transferase fucose fucosylated fucosyltransferase Fukuda functional galactose gene genomic DNA GlcNAc GlcNAc-transferase GlyCAM-1 glycans Glycobiology glycolipids glycoproteins glycosylation glycosyltransferases Golgi homologous interaction isolated lectins leukocyte leukocyte adhesion leukosialin ligand lymphocytes lysosomal mammalian mannose mannose-binding protein mediated membrane protein moieties molecular mouse mRNA mucin-type murine myeloid cells N-acetylglucosamine N-acetyllactosamine N-glycans Natl Acad neutrophils oligosaccharides p2-GlcNAc-transferase plasmid platelets PNHEV poly-N-acetyllactosamines polypeptide receptor residues saccharide Schachter selectin Shaper sialic acid sialyl sialyl-Lex sialyltransferase side chains soluble specific structure studies substrate sugar synthesis Table tissues transcript transfected transferase transmembrane domain