Human Cholinesterases and AnticholinesterasesHuman Cholinesterases and Anticholinesterases summarizes the many fundamental concepts of human cholinesterases (ChEs) and their inhibitors. This book is divided into three chapters that represent human cholinesterase research studies from different points of view. Chapter 1 deals with the biochemical and biological background of human ChEs. This chapter also examines the molecular polymorphism, genomic origin, genetic variants, and biological roles of these enzymes. Chapter 2 provides the molecular characterization of human ChE genes and their multileveled regulation, with a special emphasis on butyrylcholinesterase. Chapter 3 discusses the scientific, ecological, and clinical implications of the studies presented in the previous chapters. Protein scientists, engineers, and researchers will find this work invaluable. |
Contents
Biochemically Defined Subsites and Their Roles | 8 |
Anticholinesterases | 17 |
Cell Type and Subcellular Localization | 34 |
Copyright | |
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Common terms and phrases
acetyl acetylcholinesterase AChE activity AChE and BChE AChE DNA AChE gene AChE mRNA active site allelic alternative splicing amino acid amino acid residues analysis anionic appear atypical bambuterol BChE activity BChE gene BChE variants binding biochemical Biol blot hybridization brain BSCh Butyrylcholinesterase carbamate catalytic triad catalytically active cell lines ChEs choline cholinergic cholinergic signaling cholinesterase chorionic villi chromosome dibucaine disease displayed domain Droest6 encoding enzyme erythrocyte exons expression fetal Figure fragments function gene amplification genetic genomic Gnatt human AChE human BChE hydrolysis hydrophobic inhibition inhibitors injected insecticides interactions iso-OMPA labeling Lapidot-Lifson ligands Lockridge megakaryocytes membrane microinjected molecular molecules muscle mutations muteins neurons Neville normal nucleotide observed oocytes ovarian patients peptide peripheral phenotype platelet poisons polymorphism probe Prody protein Rabest1 receptors recombinant sequence serine serum BChE site-directed Soreq and Zakut specific structure substrate suggests tion tissues Torpedo AChE transcription tumors Xenopus oocytes