Migraine Disorders Research Trends
Migraine is a painful neurological condition, of which the most common symptom is an intense and disabling episodic headache. Migraine headaches are usually characterised by severe pain on one or both sides of the head. Absent serious head injuries, stroke, and tumours, the recurring severity of the pain indicates a vascular headache rather than a tension headache. Migraines are often accompanied by photophobia (hypersensitivity to light), phonophobia (hypersensitivity to sound) and nausea. Available evidence suggests that migraine pain is one symptom of several to many disorders of the serotonergic control system, a dual hormone-neurotransmitter with numerous types of receptors. Two disorders, classic migraine with aura (MA, STG) or common migraine without aura (MO, STG), are currently proved to be genetic. Additional migraine types are suspected and could be proved to be genetic. Migraine understood as several or many disorders could explain the inconsistencies, especially if a single patient has more than one genetic type. This book presents important new research from around the globe.
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Abnormal Brain Excitability in Migraine A Debated Subject
Migraine Disorder From Animal Models to Clinical Research
The Complex Relation between Migraine and Ischemic Stroke
Periodicity of Migraine
abnormalities activity after-effects allele allodynia amplitude analysis association blink reflex Brain Res brainstem CACNA1A CADASIL Cephalalgia cerebral blood flow cerebral cortex chromosome circadian Clin clinical clock common controls cortical excitability cortical hyperexcitability cycle disease dysfunction evidence evoked potentials excitability in migraine external carotid artery extracranial familial hemiplegic migraine frequency function gene genetic Goadsby PJ habituation healthy subjects human hypoexcitability hypothalamus increased infarction inhibition inhibitory interictal intracranial involved ischemic stroke latency linkage locus markers mechanisms melatonin migraine attacks migraine headache migraine patients migraine with aura migraine without aura migraineurs muscle mutations nerve Neurology neurons neurophysiological nociceptive occipital Olesen pathways patients with migraine pattern period polymorphism primary headaches receptor reduced response rhythms risk factors role Schoenen serotonergic serotonin somatosensory spreading depression studies superficial temporal suprachiasmatic nucleus susceptibility temporal artery threshold transcranial magnetic stimulation trigeminal trigeminovascular typical migraine Valeriani vascular visual cortex WMLs
Page 26 - Zhuchenko, O., Bailey, J., Bonnen, P., Ashizawa, T., Stockton, DW, Amos, C., Dobyns, WB, Subramony, SH, Zoghbi, HY, and Lee, CC (1997).