Imidazole and Benzimidazole Synthesis

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Academic Press, Jun 2, 1997 - Science - 265 pages
Imidazole and Benzimidazole Synthesis is a comprehensive survey of the known methods of syntheses and ring modification. It brings together the multitude of synthesis of the imidazole ring in a systemic way interms of specific bond formation, and recommends the most attractive synthetic approaches. It also collects non-ring-synthetic approaches to classes of compounds such as nitro-, halogeno-, and amino-imidazoles, and covers the synthesis of N-substituted compounds and preparations of specific isomers.
  • The only book in print dealing specifically with this topic
  • Comprehensive survey of the known methods of synthesis and ring modification
  • Recommends the most attractive synthetic approaches
 

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Contents

Chapter 1 Introduction
1
Chapter 2 Ring Synthesis by Formation of One Bond
3
4 + 1 Fragments
63
3 + 2 Fragments
103
Chapter 5 Ring Syntheses which Involve Formation of Three or Four Bonds
151
Chapter 6 Syntheses From Other Heterocycles
167
Chapter 7 Aromatic Substitution Approaches to Synthesis
193
Chapter 8 Synthesis of Specifically Substituted Imidazoles and Benzimidazoles
227
Index of Compounds and Methods
249
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Page ii - WB Motherwell and D. Crich, Free Radical Chain Reactions in Organic Synthesis, 1991 N. Petragnani, Tellurium in Organic Synthesis, 1994 T. Imamoto, Lanthanides in Organic Synthesis, 1994 AJ Pearson, Iron Compounds in Organic Synthesis, 1994 P. Metzner and A. Thuillier, Sulfur Reagents in Organic Synthesis, 1994 B.
Page ii - BEST SYNTHETIC METHODS Series Editors AR Katritzky O. Meth-Cohn CW Rees University of Florida University of Sunderland Imperial College of Science Gainesville, Florida Sunderland and Technology USA UK London, UK Richard F.

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About the author (1997)

M. Ross Grimmett was born in Dunedin, New Zealand, and he was educated at Otago and Massay Universities in New Zealand. His major research interests have been agolo allagladions and studies of nucleophilic substitution.

Alan Katritzky was educated at Oxford and has held faculty positions at Cambridge and East Anglia before he migrated in 1980 to the University of Florida, where he was Kenan Professor and Director for the Institute for Heterocyclic Compounds. During his career he has trained more than 1000 graduate students and post-docs, and lectured and consulted world-wide. He led the team, which produced “Comprehensive Heterocyclic Chemistry and its sequels, "CHEC-II" and "CHEC-III , has edited “Advances in Heterocyclic Chemistry, Vols. 1 through 111 and conceived the plan for “Comprehensive Organic Functional Group Transformations . He founded Arkat-USA, a non-profit organization which publishes “Archive for Organic Chemistry (ARKIVOC) an electronic journal completely free to authors and readers at (www.arkat-usa.org). Honors include 14 honorary doctorates from 11 countries and membership of foreign membership of the National Academies of Britain, Catalonia, India, Poland, Russia and Slovenia.

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