Tumor Angiogenesis RegulatorsRuben R. Gonzalez-Perez, Bo R. Rueda The emphasis of this book is on mechanisms and pathways regulating the expression and actions of classical and novel tumor angiogenesis regulators. The contributors discuss their underlying biology as well as anti-angiogenic drugs currently in use to fight different cancers. The book provides an insight on how factors such as obesity, diabetes, and other metabolic disorders can influence the development and growth of cancer. It is of significant interest not only to oncologists but also to a wide range of medical practitioners and researchers. |
Other editions - View all
Common terms and phrases
acid activity adenosine adiponectin angiogenesis angiogenic anti-angiogenic apoptosis bevacizumab binding Biol Chem breast cancer breast cancer cells carcinoma cathepsin cathepsin K celecoxib cell lines cell migration Chen Clin Cancer Res clinical colon cancer colorectal cyclooxygenase cyclooxygenase-2 cytokines differentiation drugs effects endometrial endothelial cells endothelial growth factor endothelial progenitor cells enhanced EPCs epithelial extracellular function gene growth factor hypoxia increased induced inflammation inflammatory influence inhibition inhibitors invasion isoforms kinase KLF5 leptin levels ligand macrophages mammary matrix mechanisms mediated metabolic metastasis mice modulate mouse NF-KB Notch signaling obesity Oncogene Oncol ovarian cancer overexpression patients PGE2 phenotype phosphorylation polymorphisms pro-angiogenic progenitor cells promote prostaglandin prostanoids prostate cancer proteases protein receptor regulation response role signaling pathways stem cells studies synthase target therapeutic therapy tissue tumor angiogenesis tumor cells tumor growth tumor microenvironment tumor progression upregulation vascular endothelial growth VEGF expression VEGFA VEGFR2 vessel vitro vivo Wang Zhang