Excitatory Amino Acid Receptors: Design of Agonists and AntagonistsPovl Krogsgaard-Larsen, Jan Jan Hansen Designed to reflect the growing awareness of the chemical aspects of excitatory amino acids, this text uses computer-based methods and X-ray techniques to depict and analyze molecules and structure-activity relationships. The book incorporates stereochemical principles into all analyses. |
Contents
structural conformational and stereochemical | 216 |
mechanism | 246 |
Kainic acid receptor agonists | 261 |
Polyamine toxins as excitatory amino acid receptor ligands | 292 |
Other editions - View all
Excitatory Amino Acid Receptors: Design of Agonists and Antagonists Povl Krogsgaard-Larsen,Jan Jan Hansen No preview available - 1992 |
Common terms and phrases
3H]AMPA binding 3H]glutamate 3H]KAIN ACRO action activity affinity amino acid amino acid receptors AMPA analogues binding sites block Brain Res Ca2+ CNQX CO₂H competitive antagonists compounds concentrations conformation COOH COOH cortex cortical Cotman depolarization DOMO Dreiding representation Drejer EAA receptors effects electrophysiological enantiomers excitatory amino acid excitotoxic extracellular Fagg glycine granule cells H₂N hippocampal Honoré ibotenic acid inhibition inhibitor interaction ion channel ionophores ischaemia JSTX KAIN KAIN receptors kainate Krogsgaard-Larsen L-AP4 receptors L-CSA L-Glu Lett ligand membrane metabotropic Qp receptors metabotropic receptor MFPA molecular molecule Monaghan Neurochem neurodegenerative neurons Neurosci neurotoxic Nielsen NMDA agonist NMDA receptor antagonists NMDA receptor complex perforant path pharmacological polyamine potent protein QUIS quisqualate receptor agonists receptor antagonists receptor subtypes regions release responses SAAs Schoepp selective Shinozaki shown stimulation structure studies subunits suggest surface and Dreiding synaptic tissue toxin trans-ACPD uptake VDW surface Watkins