Urinary Tract

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Karl-Erik Andersson, Martin C. Michel
Springer Science & Business Media, Feb 4, 2011 - Medical - 580 pages
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The basic anatomy and physiology of the urinary tract, the validity of animal models and other methodological considerations as well as a range of potential therapeutic targets are comprehensively reviewed by leading international experts, making this a unique reference source for basic scientists and research-minded clinicians alike
 

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Contents

Animal Models in Overactive Bladder Research
15
Animal Models of Stress Urinary Incontinence
45
Animal Models for Benign Prostatic Hyperplasia
68
Use of Functional Imaging to Monitor Central Control of Voiding in Humans
81
Neuroanatomy of the Lower Urinary Tract
98
Anatomy and Histology of the Lower Urinary Tract
117
Neurophysiology of the Lower Urinary Tract
149
Afferent Mechanism in the Urinary Tract
171
betaAdrenergic Receptor Subtypes in the Urinary Tract
307
Muscarinic Acetylcholine Receptors in the Urinary Tract
319
TRPV1 and Botulinum Toxin A
345
Ion Channel Modulators and Urinary Tract Function
375
Neuropeptides in Lower Urinary Tract Function
395
Potential Targets for Bladder Dysfunction
424
Vasopressin Receptors in Voiding Dysfunction
453
ATP and P2X Purinoceptors in Urinary Tract Disorders
484

Urothelial Signaling
206
Interstitial Cells of Cajal in the Urinary Tract
233
Potential Applications of Gene TherapyTransfer to the Treatment of Lower Urinary Tract DiseasesDisorders
255
Specific Pharmacokinetic Aspects of the Urinary Tract
266
α1Adrenoceptors in the Urinary Tract
283
Cyclic Nucleotide Metabolism Including Nitric Oxide and PhosphodiesteraseRelated Targets in the Lower Urinary Tract
527
RhoKinase a Common Final Path of Various Contractile Bladder and Ureter Stimuli
543
Index
569
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About the author (2011)

Karl-Erik Andersson, MD, PhD, is Professor of Regenerative Medicine and Urology at Wake Forest Institute for Regenerative Medicine. He also holds appointments in the Departments of Physiology and Pharmacology, and Molecular Medicine, at Wake Forest University School of Medicine. He has Swedish Specialist Degrees in Internal Medicine and Clinical Pharmacology, and a PhD in Pharmacology, from the University of Lund, Sweden. From 1978 to 2006 he was Professor and Chairman of the Department of Experimental and Clinical Pharmacology, University of Lund, and from 1993 to 2000 he was Vice Dean of the Medical Faculty at the University of Lund. Dr Andersson has received several awards, including a Lifetime Achievement Award from the Society for Urodynamics and Female Urology. Dr Andersson is a member of many international societies including the American Urological Association, the European Association of Urology and the International Society for Sexual Medicine. He has served on both national and international committees related to his expertise in basic and clinical physiology and pharmacology and has also served on NIH study sections in the NIDDK. He has chaired working groups for the International Consultation of Urogenital Diseases, supported by the World Health Organization. He also serves on the editorial boards of several journals, including the Journal of Urology, European Urology, and Neurourology and Urodynamics, and is Editor-in-Chief of the Urotoday International Journal. Dr Andersson has authored more than 800 articles in peer-reviewed international journals. His current research interests include clinical and basic physiology and pharmacology of the urogenital tract and regenerative medicine.