Ion Mobility Spectrometry - Mass Spectrometry: Theory and Applications

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Charles L. Wilkins, Sarah Trimpin
CRC Press, Dec 14, 2010 - House & Home - 374 pages
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The analytical power of ion mobility spectrometry-mass spectrometry (IMS-MS) instruments is poised to advance this technology from research to analytical laboratories. Exploring these developments at this critical juncture, Ion Mobility Spectrometry-Mass Spectrometry: Theory and Applications covers the tools, techniques, and applications involved when molecular size and shape information is combined with the well-known analytical advantages of high-performance mass spectrometry.

One of the Most Exciting Developments in Contemporary Mass Spectrometry
After presenting an overview chapter and the fundamentals, the book focuses on instrumentation and ionization sources. It describes an ion-mobility-capable quadrupole time-of-flight mass spectrometer, the differential mobility analyzer, a cryogenic-temperature ion mobility mass spectrometer, the atmospheric solids analysis probe method, and laserspray ionization. In the final applications-oriented chapters, the contributors explore how homebuilt and commercial instruments using electrospray ionization and matrix-assisted laser desorption/ionization (MALDI) methods are employed to solve biological and synthetic issues.

Harness the Power of IMS-MS for Analyzing Complex Substances
This work helps readers unfamiliar with IMS-MS to understand its fundamental theory and practical applications. It also encourages them to investigate the potential analytical uses of IMS-MS and further explore the power of this method. Numerous color figures are included on a CD-ROM.

  

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Contents

Chapter 1 Developments in Ion MobilityTheory Instrumentationand Applications
3
Chapter 2 Electronic State ChromatographyIon Mobility of Atomic Cations and Their Electronic States
31
Chapter 3 Measuring Ion Mobility in a Gas Jet Formed by Adiabatic Expansion
53
Instrumentation
73
Chapter 4 Development of an IonMobilityCapable Quadrupole TimeofFlight Mass Spectrometer to Examine Protein Conformation in the Gas Phase
75
Chapter 5 The Differential Mobility Analyzer DMAAdding a True MobilityDimension to a Preexisting APIMS
105
Chapter 6 A CryogenicTemperature Ion Mobility Mass Spectrometer for Improved Ion Mobility Resolution
137
Chapter 7 Multiplexed Ion Mobility Spectrometry and Ion MobilityMass Spectrometry
153
Chapter 10 Snapshot Conformationand Bulk Fragmentation Characterization of Polymeric Architectures Using ESIIMSMS
215
Chapter 11 Metabolomics by Ion MobilityMass Spectrometry
237
Chapter 12 Ion Mobility MALDI Mass Spectrometry and Its Applications
257
Chapter 13 Profiling and Imaging of Tissues by ImagingIon MobilityMass Spectrometry
269
Chapter 14 Deciphering Carbohydrate Structures by IMSMS Applications to Biological Features Related to Carbohydrate Chemistry and Biology
287
Chapter 15 Structural Characterization of OligomerAggregates of βAmyloid Polypeptide Using Ion Mobility Mass Spectrometry
313
Chapter 16 The Conformational Landscape of Biomolecules in Ion MobilityMass Spectrometry
327
Index
345

Chapter 8 IMSMS Applied to Direct Ionization Using the Atmospheric Solids Analysis Probe Method
171
Chapter 9 Total SolventFreeAnalysis Charge Remote Fragmentation and Structures of Highly Charged Lasers prayIons Using IMSMS
189
Applications
213
Back Cover
359
Copyright

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About the author (2010)

Charles L. Wilkins is a distinguished professor in the Department of Chemistry and Biochemistry at the University of Arkansas in Fayetteville. He is the editor of eight books and the author of more than 235 scientific papers and 21 book chapters. Dr. Wilkins has been the recipient of many awards, including the Southern California Section of the American Chemical Society Tolman Medal, the New York Section of the Society for Applied Spectroscopy Gold Medal, the American Chemical Society Franklin and Field Award for Outstanding Achievement in Mass Spectrometry, the Eastern Analytical Symposium Award for Outstanding Achievements in the Field of Analytical Chemistry, and the University of Oregon Alumni Award for Outstanding Achievement in Pure Chemistry. His research interests include mass spectrometry of polymer and copolymer materials, Fourier transform mass spectrometry, and the development of new methods to improve the utility of analytical mass spectrometry.

Sarah Trimpin is an assistant professor at Wayne State University in Detroit, Michigan. Dr. Trimpin has received the American Society for Mass Spectrometry Research Award, the DuPont Company Young Investigator Award, and the German Society for Mass Spectrometry Wolfgang-Paul-Studienpreis and Wolfgang-Paul-Promotionspreis. She also was honored with a National Science Foundation CAREER Award and was named one of Genome Technology’s Rising PIs. She and her colleagues recently developed laserspray ionization, a new technique that combines the attributes of MALDI and electrospray ionization.

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