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administration of anaesthesia advances in anaesthetic Alpha-2 adrenergic anaesthesia remained Anaesthesia-related mortality anaesthetic agents anaesthetic depth anaesthetic drug anaesthetic mortality anaesthetic practice anaesthetic skills anaesthetist to tailor analgesia analgesic associated with anaesthesia autonomic nervous system body's defense mechanisms chloroform control of pain controversy critically ill patients curare dramatic advances epidural ether anaesthetic extensive surgical procedures field fluid balance function Halothane Henry J Bigelow improvement in anaesthetic induction agent intensive care unit l0 000 anaesthetics learned manual skills levels of anaesthesia life-threatening management of pain Masterton maximise minimise modern anaesthesia modern anaesthetic modern anaesthetist Morton muscle relaxation nitrous oxide Nuffield Professor number of patients open drop ether operating theatre pain management patient during surgery pharmacokinetic pharmacology physiological homeostasis Post-operative fluid post-operative pain potential pulmonary oedema renal failure resulted resuscitation role side-effects specific agent specific opiate receptor studies of anaesthetic surgeon surgical patient techniques thiopentone today's anaesthetist ventilatory failure