Biology of Depression, Volume 2
Julio Licinio, Ma-Li Wong
Wiley, Mar 11, 2005 - Medical - 1095 pages
Reported by the WHO and the World Bank to be the fourth cause of disability worldwide, depression can best be explained from a genetic perspective as a complex disorder of gene-environment interactions.
This is the first major reference to cover the clinical aspects of this common and complex disorder of unknown cause. Readers will also learn about our current understanding of the psychosocial, environmental, biological, and genetic aspects of depression. The authors are internationally recognized experts from leading academic and industrial environments, and they present the features, advantages, and limitations of animal models while reviewing candidate biological systems and genetic approaches. In addition, the book covers the important topic of the medical consequences of depression, as clinicians and investigators increasingly appreciate how it negatively impacts on cardiovascular function and bone mineral density. Finally, a separate section is devoted to the biochemical and molecular basis for existing treatments, along with strategies for the use of genomic tools to discover new targets for antidepressants and to predict therapeutic outcomes.
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List of Contributors
and Prefrontal Cortex 541
Impact on Mood and Cognition
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5-HT2A receptor activity adult affective disorder allele amantadine analysis animal models antidepressant antidepressant drugs antidepressant treatment anxiety association studies BDNF behavioral binding Biol bipolar disorder Borna disease virus Brain Res candidate gene Caucasian cell chromosome chronic Clin clinical complex CREB cytokines debrisoquine depressed patients depressive disorder depressive illness depressive symptoms dopamine effects enzyme evidence fluoxetine fluvoxamine function gene expression genetic genome genotype haplotype hippocampus hormone HPA axis human identified illness immune increased inhibitors interactions kinase levels Licinio linkage studies major depression markers mediated metabolism mice module molecular monoamine mood disorders NEMEROFF neural neurons Neurosci neurotransmitter paroxetine pathways Pharmacogenetics Pharmacol phenotype plasma polymorphism population prevalence promoter protein Psychiatry Psychiatry 2001 rats receptor regulation response role sample schizophrenia sequence serotonergic serotonin transporter signaling significant SNPs stress suicide therapeutic therapy transcription factors tryptophan unipolar variation