Chemical Biophysics: Quantitative Analysis of Cellular Systems

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Cambridge University Press, May 29, 2008 - Technology & Engineering
2 Reviews
Chemical Biophysics provides an engineering-based approach to biochemical system analysis for graduate-level courses on systems biology, computational bioengineering and molecular biophysics. It is the first textbook to apply rigorous physical chemistry principles to mathematical and computational modeling of biochemical systems for an interdisciplinary audience. The book is structured to show the student the basic biophysical concepts before applying this theory to computational modeling and analysis, building up to advanced topics and research. Topics explored include the kinetics of nonequilibrium open biological systems, enzyme mediated reactions, metabolic networks, biological transport processes, large-scale biochemical networks and stochastic processes in biochemical systems. End-of-chapter exercises range from confidence-building calculations to computational simulation projects.
 

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Contents

Concepts from physical chemistry
7
Conventions and calculations for biochemical systems
24
Chemical kinetics and transport processes
41
Enzymecatalyzed reactions
69
Biochemical signaling modules
105
Biochemical reaction networks
128
Coupled biochemical systems and membrane transport
162
Spatially distributed systems and reactiondiffusion modeling
195
Constraintbased analysis of biochemical systems
220
Biomacromolecular structure and molecular association
240
Stochastic biochemical systems and the chemical master equation
261
reaction networks
267
the statistical basis of thermodynamics
282
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