Pharmacogenetics: Heredity and the Response to Drugs |
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acetylation action activity acute agents allelic anemia animals atropine atropinesterase atypical esterase bacterial barbiturates Beutler bilirubin biochemical Biol blood cause cells cent Chem choline cholinesterase chromosome Clin clinical concentration conjugation Crigler-Najjar syndrome curve defect disease dose drug resistance effect enzymatic enzyme epinephrine erythrocytes excretion Exper factors Figure flies formation genetic glaucoma glucuronic acid glucuronide glutathione groups hemoglobin hemolysis hemolytic hereditary heterozygotes heterozygous homozygous hormone houseflies human inbred indicated inheritance inhibition inhibitor injection insecticides intermediate DN investigated isoniazid jaundice Kalow kernicterus levels liver males metabolism methemoglobin methemoglobinemia mice mutation normal observed occur offspring oxidation patients penicillin persons Pharmacol pharmacologic Phenylketonuria phosphate Physiol plasma population porphyria porphyria cutanea tarda primaquine primaquine sensitivity Proc produced pyridoxine rabbits rats reactions recombination response rickets sera serum slow inactivators specific strains studies succinylcholine susceptible tion tissue toxic Tuberc types urine vitamin vitro