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abnormalities activity acute attack affected ankylosing spondylitis appear areas arteries arthralgias articular cartilage associated biopsy bone bony calcification carditis cause cells cervical changes characteristic chronic clinical colitis common connective tissue corticosteroids criteria deformity degenerative joint disease develop diagnosis disorder dose drugs early effusion erosion erythema erythrocyte sedimentation rate evidence frequently gout gouty increased infection inflammation inflammatory interphalangeal intra-articular joint involvement knee laboratory lesions lupus manifestations matoid arthritis ment metacarpophalangeal metatarsophalangeal joint mild necrosis nonspecific normal occur onset osteophytes pain particularly pathological patients with rheumatoid penicillin periosteal phenylbutazone polyarteritis polymyositis radiologic rare Raynaud's phenomenon reactions renal result rheu rheumatic disease rheumatic fever rheumatoid arthritis rheumatoid factor sacroiliac joints salicylates sclerosis secondary sedimentation rate serum uric acid severe skin spine streptococcal subchondral subcutaneous nodules surgical swelling symptoms syndrome synovial fluid tenderness tendon tion tophus toxicity treatment tumors ulcerative urate uric acid uricosuric usually wrist x-ray y-globulin